MTERF1

MTERF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3MVA, 3MVB, 3N6S, 3N7Q, 5CO0, 5CRJ, 5CKY, 5CRK
Identifiers
Aliases	MTERF1, MTERF, mitochondrial transcription termination factor 1
External IDs	OMIM: 602318; MGI: 3704243; HomoloGene: 5073; GeneCards: MTERF1; OMA:MTERF1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	91,880,702 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	4,247,651 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; testicle; ; Achilles tendon; ; lymph node; ; endometrium; ; islet of Langerhans; ; white blood cell; ; monocyte; ; gonad; ; ventricular zone;
	Top expressed in
	zygote; ; secondary oocyte; ; bone marrow; ; granulocyte; ; morula; ; embryo; ; epiblast; ; embryo; ; tail of embryo; ; primary oocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein binding; double-stranded DNA binding; RNA binding;
Cellular component	mitochondrial matrix; mitochondrial nucleoid; mitochondrion; cytosol;
Biological process	termination of mitochondrial transcription; mitochondrion organization; regulation of transcription, DNA-templated; transcription, DNA-templated; DNA geometric change; DNA-templated transcription, termination;
	Sources:Amigo / QuickGO
Orthologs
	7978
	208595
	ENSG00000127989
	ENSMUSG00000053178
	Q99551
	B9EJ57
	NM_001301134; NM_001301135; NM_006980
	NM_001042670
	NP_001288063; NP_001288064; NP_008911
	NP_001036135
	Wikidata
View/Edit Human	View/Edit Mouse

Mitochondrial transcription termination factor, also known as MTERF, is a protein which in humans is encoded by the MTERF gene.^[5]^[6]^[7]^[8]

This gene encodes a mitochondrial transcription termination factor. This protein participates in attenuating transcription from the mitochondrial genome; this attenuation allows higher levels of expression of 16S ribosomal RNA relative to the tRNA gene downstream. The product of this gene has three leucine zipper motifs bracketed by two basic domains that are all required for DNA binding. There is evidence that, for this protein, the zippers participate in intramolecular interactions that establish the three-dimensional structure required for DNA binding.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000127989 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000053178 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: MTERF mitochondrial transcription termination factor".
^ Daga A, Micol V, Hess D, Aebersold R, Attardi G (April 1993). "Molecular characterization of the transcription termination factor from human mitochondria". J. Biol. Chem. 268 (11): 8123–30. PMID 7681833.
^ Asin-Cayuela J, Helm M, Attardi G (April 2004). "A monomer-to-trimer transition of the human mitochondrial transcription termination factor (mTERF) is associated with a loss of in vitro activity". J. Biol. Chem. 279 (15): 15670–7. doi:10.1074/jbc.M312537200. PMID 14744862.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Asin-Cayuela J, Schwend T, Farge G, Gustafsson CM (July 2005). "The human mitochondrial transcription termination factor (mTERF) is fully active in vitro in the non-phosphorylated form". J. Biol. Chem. 280 (27): 25499–505. doi:10.1074/jbc.M501145200. PMID 15899902.{{cite journal}}: CS1 maint: unflagged free DOI (link)

References

Further reading