Major histocompatibility complex, class I-related

MR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4GUP, 4L4T, 4L4V, 4LCW, 4NQC, 4NQD, 4NQE, 4PJ5, 4PJ7, 4PJ8, 4PJ9, 4PJA, 4PJB, 4PJC, 4PJD, 4PJE, 4PJF, 4PJG, 4PJH, 4PJI, 4PJX, 5D7J, 5D7I, 5D5M, 5D7L
Identifiers
Aliases	MR1, HLALS, Major histocompatibility complex, class I-related
External IDs	OMIM: 600764; MGI: 1195463; HomoloGene: 123981; GeneCards: MR1; OMA:MR1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	181,061,938 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	155,022,560 bp
RNA expression pattern
	Top expressed in
	palpebral conjunctiva; ; monocyte; ; vena cava; ; stromal cell of endometrium; ; blood; ; visceral pleura; ; Achilles tendon; ; smooth muscle tissue; ; gallbladder; ; parietal pleura;
	Top expressed in
	thymus; ; ascending aorta; ; aortic valve; ; temporal muscle; ; triceps brachii muscle; ; parotid gland; ; corneal stroma; ; esophagus; ; calvaria; ; soleus muscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; MHC class I receptor activity;
Cellular component	extracellular region; endoplasmic reticulum membrane; integral component of membrane; MHC class I protein complex; membrane; endoplasmic reticulum; plasma membrane; extracellular space; external side of plasma membrane;
Biological process	cytokine production involved in immune response; antigen processing and presentation of peptide antigen via MHC class I; interleukin-1 beta production; interleukin-17 production; innate immune response; defense response to Gram-negative bacterium; immune system process; immune response; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	3140
	15064
	ENSG00000153029
	ENSMUSG00000026471
	Q95460
	Q8HWB0
NM_001194999; NM_001195000; NM_001195035; NM_001310213; NM_001531;
	NM_001385161; NM_001385162; NM_001385163; NM_001385164
	NM_008209; NM_001355062; NM_001355063
	NP_001181928; NP_001181929; NP_001181964; NP_001297142; NP_001522
	NP_032235; NP_001341991; NP_001341992
	Wikidata
View/Edit Human	View/Edit Mouse

Major histocompatibility complex class I-related gene protein is a protein that in humans is encoded by the MR1 gene.^[5]^[6]^[7] The MR1 protein is able to bind to molecules derived from bacterial riboflavin biosynthesis, and then present it to mucosal associated invariant T cells for activation.^[8]^[9]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000153029 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026471 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hashimoto K, Hirai M, Kurosawa Y (Aug 1995). "A gene outside the human MHC related to classical HLA class I genes". Science. 269 (5224): 693–5. doi:10.1126/science.7624800. PMID 7624800.
^ Yamaguchi H, Kurosawa Y, Hashimoto K (Nov 1998). "Expanded genomic organization of conserved mammalian MHC class I-related genes, human MR1 and its murine ortholog". Biochem Biophys Res Commun. 250 (3): 558–64. doi:10.1006/bbrc.1998.9353. PMID 9784382.
^ "Entrez Gene: MR1 major histocompatibility complex, class I-related".
^ Corbett, Alexandra J.; Eckle, Sidonia B. G.; Birkinshaw, Richard W.; Liu, Ligong; Patel, Onisha; Mahony, Jennifer; Chen, Zhenjun; Reantragoon, Rangsima; Meehan, Bronwyn. "T-cell activation by transitory neo-antigens derived from distinct microbial pathways". Nature. 509 (7500): 361–365. doi:10.1038/nature13160.
^ Kjer-Nielsen, Lars; Patel, Onisha; Corbett, Alexandra J.; Nours, Jérôme Le; Meehan, Bronwyn; Liu, Ligong; Bhati, Mugdha; Chen, Zhenjun; Kostenko, Lyudmila. "MR1 presents microbial vitamin B metabolites to MAIT cells". Nature. doi:10.1038/nature11605.

References

Further reading