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Chemical structure of the malonate ion.

The malonate or propanedioate ion is CH2(COO)22− (malonic acid minus two hydrogen ions). Malonate compounds include salts and esters of malonic acid, such as

Malonate is a competitive inhibitor of the enzyme succinate dehydrogenase: malonate binds to the active site of the enzyme without reacting, and so competes with succinate, the usual substrate of the enzyme. The observation that malonate is a competitive inhibitor of succinate dehydrogenase was used to deduce the structure of the active site in that enzyme.The chemical malonate decreases cellular respiration. It resembles the substrate succinate, without a -CH2-CH2 group required for dehydrogenation. [1][2]

See also[edit]


  1. ^ Potter, V. R.; Dubois, K. P. (1943). "Studies on the Mechanism of Hydrogen Transport in Animal Tissues : Vi. Inhibitor Studies with Succinic Dehydrogenase". The Journal of General Physiology. 26 (4): 391–404. PMC 2142566Freely accessible. PMID 19873352. doi:10.1085/jgp.26.4.391. 
  2. ^ Dervartanian DV, Veeger C. (November 1964). "Studies on succinate dehydrogenase. I. Spectral properties of the purified enzyme and formation of enzyme-competitive inhibitor complexes". Biochim. Biophys. Acta. 92: 233–47. PMID 14249115. doi:10.1016/0926-6569(64)90182-8.