Jump to content

Mannonate dehydratase

From Wikipedia, the free encyclopedia
mannonate dehydratase
Identifiers
EC no.4.2.1.8
CAS no.9024-31-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

The enzyme mannonate dehydratase (EC 4.2.1.8) catalyzes the chemical reaction

D-mannonate 2-dehydro-3-deoxy-D-gluconate + H2O

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is D-mannonate hydro-lyase (2-dehydro-3-deoxy-D-gluconate-forming). Other names in common use include mannonic hydrolase, mannonate hydrolyase, altronic hydro-lyase, altronate hydrolase, D-mannonate hydrolyase, and D-mannonate hydro-lyase. This enzyme participates in pentose and glucuronate interconversions.

Structural studies

[edit]

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1TZ9.

References

[edit]
  • ASHWELL A, WAHBA AJ, HICKMAN J (1958). "A new pathway of uronic acid metabolism". Biochim. Biophys. Acta. 30 (1): 186–7. doi:10.1016/0006-3002(58)90257-9. PMID 13584413.
  • Robert-Baudouy JM, Stoeber FR (1973). "[Purification and properties of D-mannonate hydrolyase from Escherichia coli K12]". Biochim. Biophys. Acta. 309 (2): 473–85. doi:10.1016/0005-2744(73)90045-4. PMID 4581499.