Gandolfi was born in Melrose, Massachusetts. He taught himself guitar as a child, studied for a year at the Berklee College of Music, and then entered NEC, where he earned his bachelors and masters degrees.
In 1986, he was a Fellow at the Tanglewood Music Center, where he studied with Leonard Bernstein and Oliver Knussen. He has served on the faculty of Harvard University, Indiana University, and the Phillips Academy at Andover. He was composer in residence with the New England Philharmonic from 1997-2000. 
Since 1997, Gandolfi has been the coordinator for the Tanglewood Music Center's composition department.
He has been championed by conductor Robert Spano as one of the "Atlanta School" of American composers, a group that includes Osvaldo Golijov, Jennifer Higdon, and Christopher Theofanidis. Gandolfi's music often contains rock and jazz elements. He sometimes looks to the sciences for his subject matter.
His The Garden of Cosmic Speculation was inspired by Charles Jencks' garden in Scotland that incorporates modern physics into its design. It was nominated for Best Contemporary Classical Composition at the 2009 Grammy Awards, His Trivia, written for the Weilerstein Trio, uses Richard Wolfson's book Simply Einstein as a source.
His works have been performed by the Boston Symphony Orchestra, Atlanta Symphony Orchestra, The New World Symphony, the Houston Symphony Orchestra, the Boston Modern Orchestra Project, BBC Scottish Symphony Orchestra, and many others.
- Michael Gandolfi website
- Video: Interview between Robert Spano & Gandolfi about the Garden piece
- Interview with Atlanta's CreativeLoafing
- Interview about the premiere of "Plain Song, Fantastic Dances"
- 2005 Boston Globe profile by Geoff Edgers
- Berklee alumni profile
- Boston Modern Orchestra Project: Boston Connections concert program notes
- EarRelevant interview
- CNN.com: A rainy bus stop and, three years later, marriage