Mitochondrial dynamics protein MID49

MIEF2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4WOY
Identifiers
Aliases	MIEF2, SMCR7, mitochondrial elongation factor 2, MID49, COXPD49
External IDs	OMIM: 615498; MGI: 2144199; HomoloGene: 27354; GeneCards: MIEF2; OMA:MIEF2 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	18,266,552 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	60,623,777 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; left ventricle; ; skeletal muscle tissue; ; prefrontal cortex; ; kidney; ; left adrenal gland; ; right adrenal gland; ; right uterine tube; ; salivary gland; ; minor salivary glands;
	Top expressed in
	knee joint; ; skeletal muscle tissue; ; quadriceps femoris muscle; ; gastrocnemius muscle; ; tibialis anterior muscle; ; ankle; ; temporal muscle; ; sternocleidomastoid muscle; ; vastus lateralis muscle; ; triceps brachii muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; identical protein binding;
Cellular component	integral component of membrane; mitochondrial outer membrane; peroxisome; membrane; mitochondrion;
Biological process	mitochondrial fusion; positive regulation of protein homooligomerization; mitochondrion organization; positive regulation of mitochondrial fission; positive regulation of protein targeting to membrane; regulation of mitochondrion organization;
	Sources:Amigo / QuickGO
Orthologs
	125170
	237781
	ENSG00000284495; ENSG00000177427
	ENSMUSG00000018599
	Q96C03
	Q5NCS9
	NM_148886; NM_001144900; NM_139162
	NM_001009927
	NP_001138372; NP_631901; NP_683684
	NP_001009927
	Wikidata
View/Edit Human	View/Edit Mouse

Mitochondrial elongation factor 2 is a protein that in humans is encoded by the MIEF2 gene. ^[5]

Function

This gene encodes an outer mitochondrial membrane protein that functions in the regulation of mitochondrial morphology. It can directly recruit the fission mediator dynamin-related protein 1 (Drp1) to the mitochondrial surface. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011].

References

^ ^a ^b ^c ENSG00000177427 GRCh38: Ensembl release 89: ENSG00000284495, ENSG00000177427 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000018599 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Mitochondrial elongation factor 2". Retrieved 2018-04-01.

Sarimski K (2004). "Communicative competence and behavioural phenotype in children with Smith-Magenis syndrome". Genet. Couns. 15 (3): 347–55. PMID 15517828.
Palmer CS, Osellame LD, Laine D, Koutsopoulos OS, Frazier AE, Ryan MT (June 2011). "MiD49 and MiD51, new components of the mitochondrial fission machinery". EMBO Rep. 12 (6): 565–73. doi:10.1038/embor.2011.54. PMC 3128275. PMID 21508961.
Palmer CS, Osellame LD, Laine D, Koutsopoulos OS, Frazier AE, Ryan MT (June 2011). "MiD49 and MiD51, new components of the mitochondrial fission machinery". EMBO Rep. 12 (6): 565–73. doi:10.1038/embor.2011.54. PMC 3128275. PMID 21508961.
Losón OC, Song Z, Chen H, Chan DC (March 2013). "Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission". Mol. Biol. Cell. 24 (5): 659–67. doi:10.1091/mbc.E12-10-0721. PMC 3583668. PMID 23283981.
Liu T, Yu R, Jin SB, Han L, Lendahl U, Zhao J, Nistér M (November 2013). "The mitochondrial elongation factors MIEF1 and MIEF2 exert partially distinct functions in mitochondrial dynamics". Exp. Cell Res. 319 (18): 2893–904. doi:10.1016/j.yexcr.2013.07.010. PMID 23880462.
Palmer CS, Elgass KD, Parton RG, Osellame LD, Stojanovski D, Ryan MT (September 2013). "Adaptor proteins MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission". J. Biol. Chem. 288 (38): 27584–93. doi:10.1074/jbc.M113.479873. PMC 3779755. PMID 23921378.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Xu S, Cherok E, Das S, Li S, Roelofs BA, Ge SX, Polster BM, Boyman L, Lederer WJ, Wang C, Karbowski M (January 2016). "Mitochondrial E3 ubiquitin ligase MARCH5 controls mitochondrial fission and cell sensitivity to stress-induced apoptosis through regulation of MiD49 protein". Mol. Biol. Cell. 27 (2): 349–59. doi:10.1091/mbc.E15-09-0678. PMC 4713136. PMID 26564796.
Otera H, Miyata N, Kuge O, Mihara K (February 2016). "Drp1-dependent mitochondrial fission via MiD49/51 is essential for apoptotic cristae remodeling". J. Cell Biol. 212 (5): 531–44. doi:10.1083/jcb.201508099. PMC 4772499. PMID 26903540.
Atkins K, Dasgupta A, Chen KH, Mewburn J, Archer SL (November 2016). "The role of Drp1 adaptor proteins MiD49 and MiD51 in mitochondrial fission: implications for human disease". Clin. Sci. 130 (21): 1861–74. doi:10.1042/CS20160030. PMID 27660309.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Template:Gene-CHR HSCHR17 3 CTG1-stub

[refGRCh38Ensembl-1] ENSG00000177427 GRCh38: Ensembl release 89: ENSG00000284495, ENSG00000177427 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000018599 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Mitochondrial elongation factor 2". Retrieved 2018-04-01.

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[5]

Function

References

Further reading