Mitotic catastrophe

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Mitotic catastrophe refers to a mechanism of delayed mitosis-linked cell death, a sequence of events resulting from premature or inappropriate entry of cells into mitosis that can be caused by chemical or physical stresses.[1] Mitotic catastrophe is unrelated to programmed cell death or apoptosis and is observed in cells lacking functional apoptotic pathways.[2] It has been observed following delayed DNA damage induced by ionizing radiation.[3] It can also be triggered by agents influencing the stability of microtubule spindles, various anticancer drugs and mitotic failure caused by defective cell cycle checkpoints.[4] Mitotic catastrophe is the primary mechanism underlying reproductive cell death in cancer cells treated with ionizing radiation.[2]

Not all cells die immediately following abnormal mitosis caused by mitotic catastrophe, but many do. Cells that do not immediately die are likely to create aneuploid cells following subsequent attempts at cell division posing a risk of oncogenesis (i.e. potentially leading to cancer). A very small fraction of these aneuploid cells produced by mitotic catastrophe might later reduce DNA ploidy by reductive division involving meiotic cell division pathways.[5][6][7]

External links[edit]

  1. ^ Ianzini F, Mackey MA (October 1997). "Spontaneous premature chromosome condensation and mitotic catastrophe following irradiation of HeLa S3 cells". International Journal of Radiation Biology. 72 (4): 409–21. doi:10.1080/095530097143185. PMID 9343106.
  2. ^ a b Ianzini F, Mackey MA (2007). "Mitotic Catastrophe". Apoptosis, Senescence, and Cancer. Humana Press. pp. 73–91. ISBN 978-1-58829-527-9.
  3. ^ Ianzini F, Mackey MA (July 1998). "Delayed DNA damage associated with mitotic catastrophe following X-irradiation of HeLa S3 cells". Mutagenesis. 13 (4): 337–44. doi:10.1093/mutage/13.4.337. PMID 9717169.
  4. ^ Castedo M, Perfettini JL, Roumier T, Andreau K, Medema R, Kroemer G (April 2004). "Cell death by mitotic catastrophe: a molecular definition". Oncogene. 23 (16): 2825–37. doi:10.1038/sj.onc.1207528. PMID 15077146.
  5. ^ Prieur-Carrillo G, Chu K, Lindqvist J, Dewey WC (June 2003). "Computerized video time-lapse (CVTL) analysis of the fate of giant cells produced by X-irradiating EJ30 human bladder carcinoma cells". Radiation Research. 159 (6): 705–12. doi:10.1667/rr3009. PMID 12751952.
  6. ^ Erenpreisa J, Kalejs M, Ianzini F, Kosmacek EA, Mackey MA, Emzinsh D, Cragg MS, Ivanov A, Illidge TM (December 2005). "Segregation of genomes in polyploid tumour cells following mitotic catastrophe". Cell Biology International. 29 (12): 1005–11. doi:10.1016/j.cellbi.2005.10.008. PMID 16314119.
  7. ^ Ianzini F, Kosmacek EA, Nelson ES, Napoli E, Erenpreisa J, Kalejs M, Mackey MA (March 2009). "Activation of meiosis-specific genes is associated with depolyploidization of human tumor cells following radiation-induced mitotic catastrophe". Cancer Research. 69 (6): 2296–304. doi:10.1158/0008-5472.can-08-3364. PMC 2657811. PMID 19258501.