Mothers against decapentaplegic

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Mothers against decapentaplegic homolog 2, one of the nine homologues of mothers against decapentaplegic.

Mothers against decapentaplegic is a protein from the SMAD family that was discovered in Drosophila. During Drosophila research, it was found that a mutation in the gene in the mother repressed the gene decapentaplegic in the embryo. The phrase "Mothers against" was added as a humorous take-off on organizations opposing various issues e.g. Mothers Against Drunk Driving (MADD); and based on a tradition of such unusual naming within the gene research community.[1]

Several human homologues are known:


  1. ^ "Sonic Hedgehog, DICER, and the Problem With Naming Genes", Sep 26, 2014, Michael White.