NASP (gene)

From Wikipedia, the free encyclopedia
Jump to: navigation, search
NASP
Identifiers
Aliases NASP, FLB7527, PRO1999, HMDRA1, nuclear autoantigenic sperm protein
External IDs MGI: 1355328 HomoloGene: 133894 GeneCards: 4678
RNA expression pattern
PBB GE NASP 201969 at tn.png

PBB GE NASP 201970 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001195193
NM_002482
NM_152298
NM_172164

NM_001081475
NM_001284229
NM_016777

RefSeq (protein)

NP_001182122.1
NP_002473.2
NP_689511.2

NP_001074944.1
NP_001271158.1

Location (UCSC) Chr 1: 45.58 – 45.62 Mb Chr 4: 116.6 – 116.63 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Nuclear autoantigenic sperm protein is a protein that in humans is encoded by the NASP gene.[1][2] Multiple isoforms are encoded by transcript variants of this gene.

Function[edit]

This gene encodes a histone H1 binding protein that is involved in transporting histones into the nucleus of dividing cells.[3] The somatic form is expressed in all mitotic cells, is localized to the nucleus, and is coupled to the cell cycle. The testicular form is expressed in embryonic tissues, tumor cells, and the testis. In male germ cells, this protein is localized to the cytoplasm of primary spermatocytes, the nucleus of spermatids, and the periacrosomal region of mature spermatozoa.[2]

References[edit]

  1. ^ O'Rand MG, Richardson RT, Zimmerman LJ, Widgren EE (Dec 1992). "Sequence and localization of human NASP: conservation of a Xenopus histone-binding protein". Dev Biol 154 (1): 37–44. doi:10.1016/0012-1606(92)90045-I. PMID 1426632. 
  2. ^ a b "Entrez Gene: NASP nuclear autoantigenic sperm protein (histone-binding)". 
  3. ^ Alekseev OM, Widgren EE, Richardson RT, O'Rand MG (January 2005). "Association of NASP with HSP90 in mouse spermatogenic cells: stimulation of ATPase activity and transport of linker histones into nuclei". J. Biol. Chem. 280 (4): 2904–11. doi:10.1074/jbc.M410397200. PMID 15533935. 

Further reading[edit]