Naa80

Crystal structure of Drosophila melanogaster Naa80. Substrate peptide is shown as yellow sticks and CoA is shown as cyan sticks. Enzyme is displayed as cyan cartoon. (PDB ID: 5WJE)

NAA80
Identifiers
Aliases	NAA80, FUS-2, FUS2, N-acetyltransferase 6, NAT6, N(alpha)-acetyltransferase 80, NatH catalytic subunit, HsNAAA80, N-alpha-acetyltransferase 80, NatH catalytic subunit
External IDs	OMIM: 607073; MGI: 1888902; HomoloGene: 36325; GeneCards: NAA80; OMA:NAA80 - orthologs
Gene location (Human) Chr. Chromosome 3 (human) Band 3p21.31 Start 50,296,402 bp End 50,299,416 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9 F1|9 58.18 cM Start 107,456,086 bp End 107,461,249 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis apex of heart right hemisphere of cerebellum granulocyte right frontal lobe skin of abdomen body of stomach right lung prefrontal cortex Top expressed in left lobe of liver seminiferous tubule lacrimal gland lip muscle of thigh right kidney spermatid choroid plexus of fourth ventricle brown adipose tissue proximal tubule More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity acyltransferase activity N-acetyltransferase activity acetyl-CoA binding peptide alpha-N-acetyltransferase activity Cellular component cytoplasm cytosol Biological process protein acetylation regulation of actin polymerization or depolymerization N-terminal peptidyl-aspartic acid acetylation N-terminal peptidyl-glutamic acid acetylation actin modification Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 24142 56441 Ensembl ENSG00000243477 ENSMUSG00000079334 UniProt Q93015 Q6IAP1 Q9R123 RefSeq (mRNA) NM_012191 NM_001200016 NM_001200018 NM_019750 RefSeq (protein) NP_001186945 NP_001186947 NP_036323 NP_001186945.1 NP_001186947.1 NP_036323.2 NP_062724 Location (UCSC) Chr 3: 50.3 – 50.3 Mb Chr 9: 107.46 – 107.46 Mb PubMed search
Wikidata
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N-acetyltransferase 80 (also known as NAT6 or FUS2) is a protein that in humans is encoded by the NAA80 gene. It acetylates the N-terminus of mature actin.

Function

This gene encodes a member of the N-acetyltransferase family. N-acetyltransferases modify proteins by transferring acetyl groups from acetyl-CoA to the N-termini of protein substrates. The encoded protein is a cytoplasmic N-acetyltransferase with a substrate specificity for N-termini that are enriched for acidic residues. This gene is located in the tumor suppressor gene region on chromosome 3p21.3, and the encoded protein may play a role in cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed. This gene overlaps and is on the same strand as hyaluronoglucosaminidase 3, and some transcripts of each gene share a portion of the first exon. [provided by RefSeq, Jan 2011].

Naa80 acetylates the N-terminus of mature actin. This N-terminal acetylation affects the rates of actin filament depolymerization and elongation, and the overall morphology of the cell.

Structure

Naa80 is a member of the GNAT family of acetyltransferases. It has an overall fold similar to the other N-terminal acetyltransferases, but has a more open, basic active site to accommodate the acidic N-terminus of actin. Naa80 can acetylate peptides with different N-terminal residues, but the presence of acidic residues in positions 2 and 3 is important for substrate specificity. Most Naa80 orthologs have an extended polyproline loop which may be important for actin binding through profilin.

Clinical Significance

Naa80 is thought to be involved in the function of the inner ear, brain and muscle, as individuals of one single family with bi-allelic mutations in NAA80 show sensorineural hearing loss, developmental delay, muscle weakness and craniofacial dysmorphisms.

Further reading

• Shuttleworth TL, Wilson MD, Wicklow BA, Wilkins JA, Triggs-Raine BL (June 2002). "Characterization of the murine hyaluronidase gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 and Hyal3". The Journal of Biological Chemistry. 277 (25): 23008–23018. doi:10.1074/jbc.M108991200. PMID 11929860.
• Zegerman P, Bannister AJ, Kouzarides T (January 2000). "The putative tumour suppressor Fus-2 is an N-acetyltransferase". Oncogene. 19 (1): 161–163. doi:10.1038/sj.onc.1203234. PMID 10644992. S2CID 3083909.
• Yi Lo PH, Chung Leung AC, Xiong W, Law S, Duh FM, Lerman MI, et al. (March 2006). "Expression of candidate chromosome 3p21.3 tumor suppressor genes and down-regulation of BLU in some esophageal squamous cell carcinomas". Cancer Letters. 234 (2): 184–192. doi:10.1016/j.canlet.2005.03.036. PMID 15885884.
• Lerman MI, Minna JD (November 2000). "The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium". Cancer Research. 60 (21): 6116–6133. PMID 11085536.
• Duh FM, Fivash M, Moody M, Li Lung M, Guo X, Stanbridge E, et al. (February 2004). "Characterization of a new SNP c767A/T (Arg222Trp) in the candidate TSG FUS2 on human chromosome 3p21.3: prevalence in Asian populations and analysis of association with nasopharyngeal cancer". Molecular and Cellular Probes. 18 (1): 39–44. doi:10.1016/j.mcp.2003.09.002. PMID 15036368.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.