NDFIP1

NDFIP1
Identifiers
Aliases	NDFIP1, N4WBP5, Nedd4 family interacting protein 1
External IDs	OMIM: 612050; MGI: 1929601; HomoloGene: 12730; GeneCards: NDFIP1; OMA:NDFIP1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	142,154,440 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	38,598,356 bp
RNA expression pattern
	Top expressed in
	Brodmann area 23; ; endothelial cell; ; pons; ; middle temporal gyrus; ; superior frontal gyrus; ; entorhinal cortex; ; postcentral gyrus; ; lateral nuclear group of thalamus; ; spinal ganglia; ; primary visual cortex;
	Top expressed in
	cingulate gyrus; ; Epithelium of choroid plexus; ; medial dorsal nucleus; ; mammillary body; ; ventral tegmental area; ; dorsomedial hypothalamic nucleus; ; ventromedial nucleus; ; median eminence; ; seminal vesicula; ; paraventricular nucleus of hypothalamus;
	More reference expression data
	n/a
Gene ontology
Molecular function	signal transducer activity; protein binding; WW domain binding;
Cellular component	integral component of membrane; endosome; membrane; Golgi membrane; extracellular region; cell cortex; perinuclear region of cytoplasm; endosome membrane; cell junction; dendrite; cell projection; neuron projection; synapse; Golgi apparatus;
Biological process	regulation of myeloid leukocyte differentiation; regulation of isotype switching to IgG isotypes; positive regulation of protein catabolic process; negative regulation of interleukin-4 production; metal ion transport; negative regulation of isotype switching to IgE isotypes; negative regulation of gene expression; negative regulation of T cell proliferation; regulation of lymphocyte differentiation; negative regulation of protein transport; negative regulation of type 2 immune response; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of protein ubiquitination; negative regulation of inflammatory response; negative regulation of transporter activity; vacuolar transport; cellular iron ion homeostasis; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	80762
	65113
	ENSG00000131507
	ENSMUSG00000024425
	Q9BT67
	Q8R0W6
	NM_030571
	NM_022996; NM_001355749
	NP_085048
	NP_075372; NP_001342678
	Wikidata
View/Edit Human	View/Edit Mouse

Nedd4 family interacting protein 1 is a protein that in humans is encoded by the NDFIP1 gene. ^[5]

Function

The protein encoded by this gene belongs to a small group of evolutionarily conserved proteins with three transmembrane domains. It is a potential target for ubiquitination by the Nedd4 family of proteins. This protein is thought to be part of a family of integral Golgi membrane proteins. [provided by RefSeq, Jul 2008].

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000131507 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024425 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Nedd4 family interacting protein 1". Retrieved 2017-10-18.

Putz U, Howitt J, Lackovic J, Foot N, Kumar S, Silke J, Tan SS (2008). "Nedd4 family-interacting protein 1 (Ndfip1) is required for the exosomal secretion of Nedd4 family proteins". J. Biol. Chem. 283 (47): 32621–7. doi:10.1074/jbc.M804120200. PMID 18819914.
Mund T, Pelham HR (2009). "Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins". EMBO Rep. 10 (5): 501–7. doi:10.1038/embor.2009.30. PMC 2680872. PMID 19343052.
Howitt J, Putz U, Lackovic J, Doan A, Dorstyn L, Cheng H, Yang B, Chan-Ling T, Silke J, Kumar S, Tan SS (2009). "Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons". Proc. Natl. Acad. Sci. U.S.A. 106 (36): 15489–94. Bibcode:2009PNAS..10615489H. doi:10.1073/pnas.0904880106. PMC 2741278. PMID 19706893.
Mund T, Pelham HR (2010). "Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2". Proc. Natl. Acad. Sci. U.S.A. 107 (25): 11429–34. Bibcode:2010PNAS..10711429M. doi:10.1073/pnas.0911714107. PMC 2895104. PMID 20534535.
Schieber C, Howitt J, Putz U, White JM, Parish CL, Donnelly PS, Tan SS (2011). "Cellular up-regulation of Nedd4 family interacting protein 1 (Ndfip1) using low levels of bioactive cobalt complexes". J. Biol. Chem. 286 (10): 8555–64. doi:10.1074/jbc.M110.203448. PMC 3048738. PMID 21187286.
Wang Y, Tong X, Ye X (2012). "Ndfip1 negatively regulates RIG-I-dependent immune signaling by enhancing E3 ligase Smurf1-mediated MAVS degradation". J. Immunol. 189 (11): 5304–13. doi:10.4049/jimmunol.1201445. PMID 23087404.
Howitt J, Gysbers AM, Ayton S, Carew-Jones F, Putz U, Finkelstein DI, Halliday GM, Tan SS (2014). "Increased Ndfip1 in the substantia nigra of Parkinsonian brains is associated with elevated iron levels". PLOS ONE. 9 (1): e87119. Bibcode:2014PLoSO...987119H. doi:10.1371/journal.pone.0087119. PMC 3901732. PMID 24475238.
Low LH, Chow YL, Li Y, Goh CP, Putz U, Silke J, Ouchi T, Howitt J, Tan SS (2015). "Nedd4 family interacting protein 1 (Ndfip1) is required for ubiquitination and nuclear trafficking of BRCA1-associated ATM activator 1 (BRAT1) during the DNA damage response". J. Biol. Chem. 290 (11): 7141–50. doi:10.1074/jbc.M114.613687. PMC 4358134. PMID 25631046.
Beck A, Shatz-Azoulay H, Vinik Y, Isaac R, Boura-Halfon S, Zick Y (2015). "Nedd4 family interacting protein 1 (Ndfip1) promotes death of pancreatic beta cells". Biochem. Biophys. Res. Commun. 465 (4): 851–6. doi:10.1016/j.bbrc.2015.08.099. PMID 26319551.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000131507 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024425 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Nedd4 family interacting protein 1". Retrieved 2017-10-18.

[1]

[2]

[3]

[4]

[5]

Function

References

Further reading