NEAT1

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NEAT1
Identifiers
AliasesNEAT1, LINC00084, NCRNA00084, TncRNA, VINC, nuclear paraspeckle assembly transcript 1 (non-protein coding), nuclear paraspeckle assembly transcript 1
External IDsGeneCards: NEAT1
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for NEAT1
Genomic location for NEAT1
Band11q13.1Start65,422,774 bp[1]
End65,445,540 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)Chr 11: 65.42 – 65.45 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Nuclear Enriched Abundant Transcript 1 (NEAT1) is a ~3.2 kb novel nuclear long non-coding RNA (RIKEN cDNA 2310043N10Rik). It is also known as Virus Inducible NonCoding RNA (VINC) or MEN epsilon RNA. It is transcribed from the multiple endocrine neoplasia locus.[3][4][5][6]

Expression of NEAT1 is induced in mouse brains during infection by Japanese encephalitis virus and rabies virus. NEAT1 is constitutively expressed in a number of non-neuronal tissues and cell lines.

NEAT1 localizes to specific nuclear structures called paraspeckles.[7] NEAT1 RNA interacts with a paraspeckle protein known as P54nrb or NONO and it is essential for paraspeckle formation. Some studies demonstrate that NEAT1 RNA is essential for the formation and maintenance of paraspeckles. Thus, this novel noncoding RNA appears to have an important structural role in the nuclear paraspeckles.[8][9]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000245532 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:".
  3. ^ Saha S, Rangarajan PN (2003). "Common host genes are activated in mouse brain by Japanese encephalitis and rabies viruses". J Gen Virol. 84 (Pt 7): 1729–35. doi:10.1099/vir.0.18826-0. PMID 12810866.
  4. ^ Saha S, Murthy S, Rangarajan PN (2006). "Identification and characterization of a virus-inducible non-coding RNA in mouse brain". J Gen Virol. 87 (Pt 7): 1991–5. doi:10.1099/vir.0.81768-0. PMID 16760401.
  5. ^ Hutchinson JN, Ensminger AW, Clemson CM, Lynch CR, Lawrence JB, Chess A (2007). "A screen for nuclear transcripts identifies two linked noncoding RNAs associated with SC35 splicing domains". BMC Genomics. 8: 39. doi:10.1186/1471-2164-8-39. PMC 1800850. PMID 17270048.
  6. ^ "Entrez Gene: nuclear paraspeckle assembly transcript 1 (non-protein coding)".
  7. ^ Sunwoo H, Dinger ME, Wilusz JE, Amaral PP, Mattick JS, Spector DL (2009). "MEN epsilon/beta nuclear-retained non-coding RNAs are up-regulated upon muscle differentiation and are essential components of paraspeckles". Genome Res. 19 (3): 347–59. doi:10.1101/gr.087775.108. PMC 2661813. PMID 19106332.
  8. ^ Sasaki YT, Ideue T, Sano M, Mituyama T, Hirose T (2009). "MENepsilon/beta noncoding RNAs are essential for structural integrity of nuclear paraspeckles". Proc Natl Acad Sci U S A. 106 (8): 2525–30. doi:10.1073/pnas.0807899106. PMC 2650297. PMID 19188602.
  9. ^ Clemson CM, Hutchinson JN, Sara SA, Ensminger AW, Fox AH, Chess A, Lawrence JB (2009). "An architectural role for a nuclear noncoding RNA: NEAT1 RNA is essential for the structure of paraspeckles". Mol Cell. 33 (6): 717–26. doi:10.1016/j.molcel.2009.01.026. PMC 2696186. PMID 19217333.

Further reading[edit]