NEDD1

NEDD1
Identifiers
Aliases	NEDD1, GCP-WD, TUBGCP7, neural precursor cell expressed, developmentally down-regulated 1, NEDD1 gamma-tubulin ring complex targeting factor
External IDs	OMIM: 600372; MGI: 97293; HomoloGene: 7439; GeneCards: NEDD1; OMA:NEDD1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	96,953,780 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	92,558,282 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; Skeletal muscle tissue of rectus abdominis; ; biceps brachii; ; sperm; ; vastus lateralis muscle; ; deltoid muscle; ; buccal mucosa cell; ; ventricular zone; ; Skeletal muscle tissue of biceps brachii; ; tibialis anterior muscle;
	Top expressed in
	secondary oocyte; ; atrium; ; right ventricle; ; cardiac muscles; ; digastric muscle; ; myocardium of ventricle; ; triceps brachii muscle; ; yolk sac; ; sternocleidomastoid muscle; ; medial ganglionic eminence;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; microtubule organizing center; ciliary basal body; centriole; cytosol; centrosome; apical part of cell; spindle pole; pericentriolar material; cytoskeleton;
Biological process	cell division; protein localization to centrosome; cell cycle; G2/M transition of mitotic cell cycle; ciliary basal body-plasma membrane docking; regulation of G2/M transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	121441
	17997
	ENSG00000139350
	ENSMUSG00000019988
	Q8NHV4
	P33215
	NM_001135175; NM_001135176; NM_001135177; NM_152905
	NM_008682
	NP_001128647; NP_001128648; NP_001128649; NP_690869
	NP_032708
	Wikidata
View/Edit Human	View/Edit Mouse

Neural precursor cell expressed, developmentally down-regulated 1, also known as Nedd1, is a human gene ^[5] and encodes the protein NEDD1.

NEDD1 is localized in the centrosome and it plays a role in mitosis through its interaction with γ-tubulin. WD40 repeats are located in the amino-terminal of the protein and are responsible for NEDD1 localization in the centrosome, and the carboxy-terminal amino acids are needed for interactions with γ-tubulin. Depletion of NEDD1 causes impaired centrosome and chromatin microtubules assembly that results in the failure of microtubule nucleation and prevents proper spindle formation.

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000139350 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019988 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: NEDD1 neural precursor cell expressed, developmentally down-regulated 1".

References

Further reading