NEGR1

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NEGR1
Identifiers
Aliases NEGR1, DMML2433, IGLON4, KILON, Ntra, neuronal growth regulator 1
External IDs MGI: 2444846 HomoloGene: 41447 GeneCards: NEGR1
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_173808

NM_001039094
NM_177274

RefSeq (protein)

NP_776169

NP_001034183.1
NP_796248.1
NP_001034183
NP_796248

Location (UCSC) Chr 1: 71.4 – 72.28 Mb Chr 3: 156.56 – 157.32 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Neuronal growth regulator 1 also known as NEGR1 is a protein which in humans is encoded by the NEGR1 gene.[3]

Clinical significance[edit]

Variants of the NEGR1 gene may be associated with obesity.[4][5][6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Funatsu N, Miyata S, Kumanogoh H, Shigeta M, Hamada K, Endo Y, Sokawa Y, Maekawa S (March 1999). "Characterization of a novel rat brain glycosylphosphatidylinositol-anchored protein (Kilon), a member of the IgLON cell adhesion molecule family". J. Biol. Chem. 274 (12): 8224–30. doi:10.1074/jbc.274.12.8224. PMID 10075727. 
  4. ^ Thorleifsson G, Walters GB, Gudbjartsson DF, et al. (January 2009). "Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.". Nat. Genet. 41 (1): 18–24. doi:10.1038/ng.274. PMID 19079260. 
  5. ^ Willer CJ, Speliotes EK, Loos RJ, et al. (January 2009). "Six new loci associated with body mass index highlight a neuronal influence on body weight regulation". Nat. Genet. 41 (1): 24–34. doi:10.1038/ng.287. PMC 2695662Freely accessible. PMID 19079261. 
  6. ^ Zhao J, Bradfield JP, Li M, et al. (May 2009). "The role of obesity-associated loci identified in genome wide association studies in the determination of pediatric BMI". Obesity (Silver Spring). 17 (12): 2254–7. doi:10.1038/oby.2009.159. PMC 2860782Freely accessible. PMID 19478790. 

Further reading[edit]