NEMF (gene)

NEMF
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3J92
Identifiers
Aliases	NEMF, NY-CO-1, SDCCAG1, nuclear export mediator factor, IDDSAPN
External IDs	OMIM: 608378; MGI: 1918305; HomoloGene: 3458; GeneCards: NEMF; OMA:NEMF - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	49,852,821 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	69,403,939 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; internal globus pallidus; ; sperm; ; Brodmann area 23; ; pylorus; ; corpus callosum; ; external globus pallidus; ; epithelium of colon; ; sural nerve; ; inferior ganglion of vagus nerve;
	Top expressed in
	hand; ; seminal vesicula; ; mammillary body; ; lobe of prostate; ; ventromedial nucleus; ; lateral geniculate nucleus; ; fossa; ; lateral hypothalamus; ; pineal gland; ; lateral septal nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	tRNA binding; ribosomal large subunit binding;
Cellular component	nucleus; RQC complex;
Biological process	nuclear export; rescue of stalled ribosome; ribosome-associated ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	9147
	66244
	ENSG00000165525
	ENSMUSG00000020982
	O60524
	Q8CCP0
	NM_001301732; NM_004713
	NM_025441; NM_181665
	NP_001288661; NP_004704
	NP_079717
	Wikidata
View/Edit Human	View/Edit Mouse

Nuclear export mediator factor (NEMF) is a protein that in humans is encoded by the NEMF gene.^[5]

Function

This gene encodes a component of the ribosome quality control complex.^[6] The encoded protein facilitates the recognition and ubiquitination of stalled 60S subunits by the ubiquitin ligase listerin. A similar protein in fly functions as a tumor suppressor.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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