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Available structures
PDB Ortholog search: PDBe RCSB
Aliases BEX3, Bex, DXS6984E, HGR74, NADE, NGFRAP1, brain expressed X-linked 3
External IDs MGI: 1338016 HomoloGene: 7642 GeneCards: BEX3
RNA expression pattern
PBB GE NGFRAP1 217963 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)


Location (UCSC) Chr X: 103.38 – 103.38 Mb Chr X: 136.27 – 136.27 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Protein BEX3 is a protein that in humans is encoded by the NGFRAP1 gene.[3][4][5]


NGFRAP1 has been shown to interact with YWHAE[6] and Low affinity nerve growth factor receptor.[3]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b Mukai J, Hachiya T, Shoji-Hoshino S, Kimura MT, Nadano D, Suvanto P, Hanaoka T, Li Y, Irie S, Greene LA, Sato TA (Jul 2000). "NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR". J. Biol. Chem. 275 (23): 17566–70. doi:10.1074/jbc.C000140200. PMID 10764727. 
  4. ^ Rapp G, Freudenstein J, Klaudiny J, Mucha J, Wempe F, Zimmer M, Scheit KH (Dec 1990). "Characterization of three abundant mRNAs from human ovarian granulosa cells". DNA Cell Biol. 9 (7): 479–85. doi:10.1089/dna.1990.9.479. PMID 2171551. 
  5. ^ "Entrez Gene: NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1". 
  6. ^ Kimura MT, Irie S, Shoji-Hoshino S, Mukai J, Nadano D, Oshimura M, Sato TA (May 2001). "14-3-3 is involved in p75 neurotrophin receptor-mediated signal transduction". J. Biol. Chem. 276 (20): 17291–300. doi:10.1074/jbc.M005453200. PMID 11278287. 

Further reading[edit]

  • Auffray C, Behar G, Bois F, Bouchier C, Da Silva C, Devignes MD, Duprat S, Houlgatte R, Jumeau MN, Lamy B (1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression]". C. R. Acad. Sci. III, Sci. Vie. 318 (2): 263–72. PMID 7757816. 
  • Ye X, Mehlen P, Rabizadeh S, VanArsdale T, Zhang H, Shin H, Wang JJ, Leo E, Zapata J, Hauser CA, Reed JC, Bredesen DE (1999). "TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction". J. Biol. Chem. 274 (42): 30202–8. doi:10.1074/jbc.274.42.30202. PMID 10514511. 
  • Irie S, Hachiya T, Rabizadeh S, Maruyama W, Mukai J, Li Y, Reed JC, Bredesen DE, Sato TA (1999). "Functional interaction of Fas-associated phosphatase-1 (FAP-1) with p75(NTR) and their effect on NF-kappaB activation". FEBS Lett. 460 (2): 191–8. doi:10.1016/S0014-5793(99)01324-1. PMID 10544233. 
  • Bilderback TR, Gazula VR, Dobrowsky RT (2001). "Phosphoinositide 3-kinase regulates crosstalk between Trk A tyrosine kinase and p75(NTR)-dependent sphingolipid signaling pathways". J. Neurochem. 76 (5): 1540–51. doi:10.1046/j.1471-4159.2001.00171.x. PMID 11238738. 
  • Kimura MT, Irie S, Shoji-Hoshino S, Mukai J, Nadano D, Oshimura M, Sato TA (2001). "14-3-3 is involved in p75 neurotrophin receptor-mediated signal transduction". J. Biol. Chem. 276 (20): 17291–300. doi:10.1074/jbc.M005453200. PMID 11278287. 
  • Mukai J, Shoji S, Kimura MT, Okubo S, Sano H, Suvanto P, Li Y, Irie S, Sato TA (2002). "Structure-function analysis of NADE: identification of regions that mediate nerve growth factor-induced apoptosis". J. Biol. Chem. 277 (16): 13973–82. doi:10.1074/jbc.M106342200. PMID 11830582. 
  • Tong X, Xie D, Roth W, Reed J, Koeffler HP (2003). "NADE (p75NTR-associated cell death executor) suppresses cellular growth in vivo". Int. J. Oncol. 22 (6): 1357–62. doi:10.3892/ijo.22.6.1357. PMID 12739005. 
  • Yoon K, Jang HD, Lee SY (2004). "Direct interaction of Smac with NADE promotes TRAIL-induced apoptosis". Biochem. Biophys. Res. Commun. 319 (2): 649–54. doi:10.1016/j.bbrc.2004.05.043. PMID 15178455. 
  • Alvarez E, Zhou W, Witta SE, Freed CR (2005). "Characterization of the Bex gene family in humans, mice, and rats". Gene. 357 (1): 18–28. doi:10.1016/j.gene.2005.05.012. PMID 15958283. 
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Yu Y, Wang J, Yuan H, Qin F, Wang J, Zhang N, Li YY, Liu J, Lu H (2006). "Characterization of human dopamine responsive protein DRG-1 that binds to p75NTR-associated cell death executor NADE". Brain Res. 1100 (1): 13–20. doi:10.1016/j.brainres.2006.05.010. PMID 16777077. 
  • Yasui S, Tsuzaki K, Ninomiya H, Floricel F, Asano Y, Maki H, Takamura A, Nanba E, Higaki K, Ohno K (2007). "The TSC1 gene product hamartin interacts with NADE". Mol. Cell. Neurosci. 35 (1): 100–8. doi:10.1016/j.mcn.2007.02.007. PMID 17355907.