NINJ1

NINJ1
Identifiers
Aliases	NINJ1, NIN1, NINJURIN, ninjurin 1
External IDs	OMIM: 602062; MGI: 1196617; HomoloGene: 88815; GeneCards: NINJ1; OMA:NINJ1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	93,134,251 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	49,349,720 bp
RNA expression pattern
	Top expressed in
	right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; monocyte; ; thoracic aorta; ; ascending aorta; ; Descending thoracic aorta; ; right lobe of liver; ; blood; ; gastric mucosa;
	Top expressed in
	stroma of bone marrow; ; pyloric antrum; ; right kidney; ; left lobe of liver; ; facial motor nucleus; ; calvaria; ; utricle; ; tibiofemoral joint; ; vestibular sensory epithelium; ; primary oocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	integral component of membrane; membrane;
Biological process	hyaloid vascular plexus regression; cell adhesion; nervous system development; tissue regeneration; positive regulation of cell-matrix adhesion; pyroptosis; cell death;
	Sources:Amigo / QuickGO
Orthologs
	4814
	18081
	ENSG00000131669
	ENSMUSG00000037966
	Q92982
	O70131
	NM_004148
	NM_013610
	NP_004139
	NP_038638
	Wikidata
View/Edit Human	View/Edit Mouse

Ninjurin-1 is a protein that in humans is encoded by the NINJ1 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000131669 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037966 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Araki T, Milbrandt J (Oct 1996). "Ninjurin, a novel adhesion molecule, is induced by nerve injury and promotes axonal growth". Neuron. 17 (2): 353–61. doi:10.1016/S0896-6273(00)80166-X. PMID 8780658. S2CID 12471778.
^ "Entrez Gene: NINJ1 ninjurin 1".

Guimarães PE, Fridman C, Gregório SP, et al. (2007). "WITHDRAWN: Association between polymorphisms in genes of inflammatory response and axonal repair with spinal cord injury". Spinal Cord. doi:10.1038/sj.sc.3102122. PMID 17893696.
Cardoso CC, Martinez AN, Guimarães PE, et al. (2007). "Ninjurin 1 asp110ala single nucleotide polymorphism is associated with protection in leprosy nerve damage". J. Neuroimmunol. 190 (1–2): 131–8. doi:10.1016/j.jneuroim.2007.07.015. PMID 17825431. S2CID 20637695.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Toyama T, Sasaki Y, Horimoto M, et al. (2005). "Ninjurin1 increases p21 expression and induces cellular senescence in human hepatoma cells". J. Hepatol. 41 (4): 637–43. doi:10.1016/j.jhep.2004.06.027. PMID 15464245.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Chadwick BP, Heath SK, Williamson J, et al. (1998). "The human homologue of the ninjurin gene maps to the candidate region of hereditary sensory neuropathy type I (HSNI)". Genomics. 47 (1): 58–63. doi:10.1006/geno.1997.5084. PMID 9465296.
Araki T, Zimonjic DB, Popescu NC, Milbrandt J (1997). "Mechanism of homophilic binding mediated by ninjurin, a novel widely expressed adhesion molecule". J. Biol. Chem. 272 (34): 21373–80. doi:10.1074/jbc.272.34.21373. PMID 9261151.

Degen, Morris; Santos, José Carlos; Pluhackova, Kristyna; Cebrero, Gonzalo; Ramos, Saray; Jankevicius, Gytis; Hartenian, Ella; Guillerm, Undina; Mari, Stefania A.; Kohl, Bastian; Müller, Daniel J.; Schanda, Paul; Maier, Timm; Perez, Camilo; Sieben, Christian (2023-06-29). "Structural basis of NINJ1-mediated plasma membrane rupture in cell death". Nature. 618 (7967): 1065–1071. doi:10.1038/s41586-023-05991-z. ISSN 0028-0836. PMC 10307626. PMID 37198476.
Pourmal, Sergei; Truong, Melissa E.; Johnson, Matthew C.; Yang, Ying; Zhou, Lijuan; Alegre, Kamela; Stowe, Irma B.; Gupta, Shalini; Chen, Phoebe A.; Zhang, Yingnan; Rohou, Alexis; Newton, Kim; Kayagaki, Nobuhiko; Dixit, Vishva M.; Deshpande, Ishan (2024-10-30). "Autoinhibition of dimeric NINJ1 prevents plasma membrane rupture". Nature: 1–3. doi:10.1038/s41586-024-08273-4. ISSN 1476-4687.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000131669 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037966 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8780658-5] Araki T, Milbrandt J (Oct 1996). "Ninjurin, a novel adhesion molecule, is induced by nerve injury and promotes axonal growth". Neuron. 17 (2): 353–61. doi:10.1016/S0896-6273(00)80166-X. PMID 8780658. S2CID 12471778.

[entrez-6] "Entrez Gene: NINJ1 ninjurin 1".

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References

Further reading