NLGN3

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NLGN3
Identifiers
Aliases NLGN3, HNL3, neuroligin 3
External IDs MGI: 2444609 HomoloGene: 23133 GeneCards: NLGN3
Gene location (Human)
X chromosome (human)
Chr. X chromosome (human)[1]
X chromosome (human)
Genomic location for NLGN3
Genomic location for NLGN3
Band Xq13.1 Start 71,144,831 bp[1]
End 71,171,201 bp[1]
RNA expression pattern
PBB GE NLGN3 219726 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001166660
NM_018977
NM_181303
NM_001321276

NM_172932

RefSeq (protein)

NP_001160132
NP_001308205
NP_061850
NP_851820
NP_001160132.1

NP_766520

Location (UCSC) Chr X: 71.14 – 71.17 Mb Chr X: 101.3 – 101.33 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Neuroligin-3 is a protein that in humans is encoded by the NLGN3 gene.[5][6][7]

This gene encodes a member of the neuroligin family of neuronal cell surface proteins. Neuroligins may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with Autism Spectrum Disorders (ASDs). Multiple transcript variants encoding distinct isoforms have been identified for this gene, but their full length sequences have not been determined.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000196338 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031302 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Philibert RA, Winfield SL, Sandhu HK, Martin BM, Ginns EI (May 2000). "The structure and expression of the human neuroligin-3 gene". Gene. 246 (1–2): 303–10. doi:10.1016/S0378-1119(00)00049-4. PMID 10767552. 
  6. ^ Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (Sep 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331. 
  7. ^ a b "Entrez Gene: NLGN3 neuroligin 3". 

Further reading[edit]