NPTN

From Wikipedia, the free encyclopedia
Jump to: navigation, search
NPTN
Identifiers
Aliases NPTN, GP55, GP65, SDFR1, SDR1, np55, np65, neuroplastin
External IDs HomoloGene: 7531 GeneCards: NPTN
RNA expression pattern
PBB GE NPTN 202228 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001161363
NM_001161364
NM_012428
NM_017455

n/a

RefSeq (protein)

NP_001154835
NP_001154836
NP_036560
NP_059429

n/a

Location (UCSC) Chr 15: 73.56 – 73.63 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

Neuroplastin is a protein that in humans is encoded by the NPTN gene.[2][3][4]

Neuroplastin is a type I transmembrane protein belonging to the Ig superfamily. The protein is believed to be involved in cell-cell interactions or cell-substrate interactions. The alpha and beta transcripts show differential localization within the brain.[4]

In 2014, in a study led by Dr. Sylvane Desrivières, of King's College London's Institute of Psychiatry found that "teenagers who had a highly functioning NPTN gene performed better in intelligence tests"[5][6][7]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Jun 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474. 
  3. ^ Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Jun 1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146Freely accessible. PMID 9110174. 
  4. ^ a b "Entrez Gene: NPTN neuroplastin". 
  5. ^ Is intelligence written in the genes?
  6. ^ Researchers Find Gene that Links Grey Matter with Intelligence
  7. ^ Single nucleotide polymorphism in the neuroplastin locus associates with cortical thickness and intellectual ability in adolescents

Further reading[edit]