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Aliases NXF2, CT39, TAPL-2, TCP11X2, nuclear RNA export factor 2
External IDs MGI: 1933192 HomoloGene: 88604 GeneCards: NXF2
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr X: 102.25 – 102.33 Mb Chr X: 134.94 – 134.96 Mb
PubMed search [1] [2]
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Nuclear RNA export factor 2 is a protein that in humans is encoded by the NXF2 gene.[3][4][5]


This gene is one of a family of nuclear RNA export factor genes. It encodes a protein that is involved in mRNA export, is located in the nucleoplasm, and is associated with the nuclear envelope. Alternative splicing seems to be a common mechanism in this gene family. Two variants have been found for this gene.[5]


NXF2 has been shown to interact with NUP214.[3]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b Herold A, Suyama M, Rodrigues JP, Braun IC, Kutay U, Carmo-Fonseca M, Bork P, Izaurralde E (Dec 2000). "TAP (NXF1) belongs to a multigene family of putative RNA export factors with a conserved modular architecture". Molecular and Cellular Biology. 20 (23): 8996–9008. doi:10.1128/MCB.20.23.8996-9008.2000. PMC 86553Freely accessible. PMID 11073998. 
  4. ^ Wang PJ, McCarrey JR, Yang F, Page DC (Apr 2001). "An abundance of X-linked genes expressed in spermatogonia". Nature Genetics. 27 (4): 422–426. doi:10.1038/86927. PMID 11279525. 
  5. ^ a b "Entrez Gene: NXF2 nuclear RNA export factor 2". 

Further reading[edit]

  • Black BE, Lévesque L, Holaska JM, Wood TC, Paschal BM (Dec 1999). "Identification of an NTF2-related factor that binds Ran-GTP and regulates nuclear protein export". Molecular and Cellular Biology. 19 (12): 8616–24. PMC 84993Freely accessible. PMID 10567585. 
  • Jun L, Frints S, Duhamel H, Herold A, Abad-Rodrigues J, Dotti C, Izaurralde E, Marynen P, Froyen G (Sep 2001). "NXF5, a novel member of the nuclear RNA export factor family, is lost in a male patient with a syndromic form of mental retardation". Current Biology. 11 (18): 1381–1391. doi:10.1016/S0960-9822(01)00419-5. PMID 11566096. 
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514.