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The neck dissection is a surgical procedure for control of neck lymph node metastasis. This can be done for clinically or radiologically evident lymph nodes or as part of curative surgery where risk of occult nodal metastasis is deemed sufficiently high. The aim of the procedure is to remove lymph nodes from the neck into which cancer cells may have migrated. Metastasis of tumours into the lymph nodes of the neck is one of the strongest prognostic indicators for head and neck cancer. The metastases may originate from tumours of the upper aerodigestive tract, including the oral cavity, tongue, nasopharynx, oropharynx, hypopharynx, and larynx, as well as the thyroid, parotid and posterior scalp. Neck nodal metastasis can sometimes also originate from lung cancer or intra-abdominal malignancy. However, neck dissection is rarely performed for such purposes.
Lymph nodes in a particular region are numerous and generally referred to in groups. It is impossible to dissect through all the soft tissue to remove individual lymph nodes. As such the neck dissection is the en-bloc resection of all soft tissue in the region including all the lymph nodes and structures passing through them. In the case of a neck dissection, this entails the resection of everything within the superficial layer of deep cervical fascia (also known as the investing layer of cervical fascia). Where deemed excessively morbid, the structures within are conserved. These include the carotid and in some instances the three structures - IJV, SCM and Accessory Nerve.
History of Neck Dissections
- 1888 - Jawdynski described en bloc resection with resection of carotid, internal jugular vein and sternocleidomastoid muscle.
- 1906 - George W. Crile of the Cleveland Clinic describes the radical neck dissection. The operation encompasses removal of all the lymph nodes on one side of the neck, and includes removal of the spinal accessory nerve (SAN, or CN XI), internal jugular vein (IJV) and sternocleidomastoid muscle (SCM).
- 1957 - Hayes Martin describes routine use of the radical neck dissection for control of neck metastases.
- 1967 - Oscar Suarez and E. Bocca describe a more conservative operation which preserves SAN, IJV and SCM.
- Last 3 decades - Further operations have been described to selectively remove the involved regional lymph groups.
Division of the Neck into Levels and Sublevels
Memorial Sloan-Kettering Cancer Center developed the lymph node regional definitions most widely used today.
To describe the lymph nodes of the neck for neck dissection, the neck is divided into 6 areas called Levels. The levels are identified by Roman numeral, increasing towards the chest. A further Level VII to denote lymph node groups in the superior mediastinum is no longer used. Instead, lymph nodes in other non-neck regions are referred to by the name of their specific nodal groups.
- Region I: Submental and submandibular triangles. Ia is the submental triangle bound by the anterior bellies of the digastric and the mylohyoid. Ib is the triangle formed by the anterior and posterior bellies of the digastric and body of mandible.
Region II, III, IV: nodes associated with the IJV; fibroadipose tissue located medial to the posterior border of SCM and lateral to the border of the sternohyoid.
- Region II: upper third including the upper jugular and jugulodigastric nodes and the upper posterior cervical nodes. Region bound by the digastric muscle superiorly and the hyoid bone (clinical landmark), or the carotid bifurcation (surgical landmark) inferiorly. IIa contains nodes in the region anterior to the spinal accessory nerve and IIb postero-superior to the nerve.
- Region III: middle third jugular nodes extending from the carotid bifurcation superiorly to the cricothyroid notch (clinical landmark), or inferior edge of cricoid cartilage (radiological landmark), or omohyoid muscle (surgical landmark).
- Region IV: lower jugular nodes extending from the omohyoid muscle superiorly to the clavicle inferiorly.
- Region V: posterior triangle group of lymph nodes located along the lower half of the spinal accessory nerve and the transverse cervical artery. The supraclavicular nodes are also included in this group. The posterior boundary is the anterior border of the trapezius muscle, the anterior boundary is the posterior border of the sternocleidomastoid muscle, and the inferior boundary is the clavicle.
- Region VI: anterior compartment group comprises lymph nodes surrounding the midline visceral structures of the neck extending from the level of the hyoid bone superiorly to the suprasternal notch inferiorly. On each side, the lateral boundary is the medial border of the carotid sheath. Located within this compartment are the perithyroidal lymph nodes, paratracheal lymph nodes, lymph nodes along the recurrent laryngeal nerves, and precricoid lymph nodes. (4)
Staging of head and neck cancer
The staging of head and neck cancer includes a classification for nodal disease. It is important to note the critical difference in size of nodes with break points at 3 and 6 cm. The staging system for head and neck malignancies considers all malignancies with palpable cervical adenopathy as Stage 3 or Stage 4, reflecting the grim prognostic implications of palpable nodal disease. (2) The most important prognostic indicator in patients with squamous carcinoma of the head and neck remains the status of the cervical lymph nodes. (3)
NX: Regional lymph nodes cannot be assessed
N0: No regional lymph node metastasis
N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension
N2a: Metastasis in a single ipsilateral lymph node more than 3 cm but not more than 6 cm in greatest dimension
N2b: Metastasis in multiple ipsilateral lymph nodes, none more than 6 cm in greatest dimension
N2c: Metastasis in bilateral or contralateral nodes, no more than 6 cm in greatest dimension
N3: Metastasis in a lymph node more than 6 cm in greatest dimension (2)
Classification of Neck Dissections
The 2001 revisions proposed by the American Head and Neck Society (AHNS) and the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) are as follows.
- Radical Neck Dissection (RND) - removal of all ipsilateral cervical lymph node groups from levels I through V, together with SAN, SCM and IJV.
- Modified Radical Neck Dissection (MRND) - removal of all lymph node groups routinely removed in a RND, but with preservation of one or more nonlymphatic structures (SAN, SCM and IJV).
- Selective Neck Dissection (SND) (together with the use of parentheses to denote the levels or sublevels removed) - cervical lymphadenectomy with preservation of one or more lymph node groups that are routinely removed in a RND. Thus for oral cavity cancers, SND (I-III) is commonly performed. For oropharyngeal, hypopharyngeal and laryngeal cancers, SND (II-IV) is the procedure of choice.
- Extended Neck Dissection - This refers to removal of one or more additional lymph node groups or nonlymphatic structures, or both, not encompassed by the RND.
The radical neck dissection is defined as removing all of the lymphatic tissue in regions I-V including removal of the spinal accessory nerve (SAN), sternocleidomastoid muscle (SCM), and internal jugular vein (IJV). It does not include removal of the suboccipital nodes, periparotid nodes except for infraparotid nodes located in the posterior aspect of the submandibular triangle, buccal nodes, retropharyngeal nodes, or paratracheal nodes. (4)
Modified radical neck dissection (MRND) is defined as excision of all lymph nodes routinely removed by radical neck dissection with preservation of one or more nonlymphatic structures, i.e., SAN, IJV, SCM. (4) Medina subclassifies the MRND into types I-III; where type I MRND preserves the SAN, type II MRND preserves the SAN and SCM, and type III MRND preserves the SAN, SCM, and IJV. The type III MRND is also referred to as the "functional neck dissection" as popularized by Bocca, however in his classic description the submandibular gland is not excised. (5)
Selective neck dissection is defined as any type of cervical lymphadenectomy where there is preservation of one or more lymph node groups removed by the radical neck dissection. There are four common subtypes, the first of which is the supraomohyoid neck dissection. This removes lymph tissue contained in regions I-III. The posterior limit of the dissection is marked by the cutaneous branches of the cervical plexus and the posterior border of the SCM. The inferior limit is the superior belly of the omohyoid muscle where it crosses the IJV. The second subtype, posterolateral neck dissection, refers to the removal of the suboccipital lymph nodes, retroauricular lymph nodes, levels II-IV, and level V. This procedure is used most often to remove nodal disease from cutaneous melanoma of the posterior scalp and neck. (4) Originally described by Rochlin in 1962, the SAN, SCM, and IJV were preserved. Medina suggests subclassification of the posteriolateral neck dissection to types I-III to mirror preservation of SAN, IJV, and SCM as in MRND. (5) The lateral neck dissection removes lymph tissue in levels II-IV. Anterior neck dissection is the last subtype of selective neck dissection and refers to the removal of lymph nodes surrounding the visceral structures of the anterior aspect of the neck previously defined as level VI.(4)
The last major subtype is the extended neck dissection defined literally as removal of one or more additional lymph node groups and/or nonlymphatic structures not encompassed by radical neck dissection, such as parapharyngeal, superior mediastinal, and paratracheal. In practice, any of the previous neck dissections may be extended to include other structures. With those definitions in place, the evolution and current indications of the various neck dissections shall be discussed.
- Neck dissection: an operation in evolution in World Journal of Surgical Oncology - 8 references
- Head and Neck Cancer - Resection and Neck Dissection - Relevant Anatomy
Much of original article seems based on Neck Dissection: Classification, Indication, and Technique Buckingham 1998.
- References Cited (n):
- 1. Bailey, Byron J. Head and Neck Surgery-Otolaryngology, Second Edition. Lippincott-Raven, Philadelphia-New York. 1998.
- 2. Meyers, Eugene N. Operative Otolaryngology-Head and Neck Surgery. W. B. Saunders Company, Philadelphia, Pennsylvania. 1997.
- 3. Shah, Jatin P., The Impact of Patterns of Nodal Metastasis on Modifications of Neck Dissection, Ann Surg Oncol, 1994;1(6):521-532.
- 4. Robbins, Thomas K., Standardizing Neck Dissection Terminology, Arch tolaryngol Head Neck Surg, June 1991; 117:601-605.
- 5. Medina, Jesus E., A Rational Classification of Neck Dissections, Otolaryngology Head and Neck Surgery, March 1989; 100:169-176.
- 6. Anderson, Peter E., The Role of Comprehensive Neck Dissection With Preservation of the Spinal Accessory Nerve in the Clinically Positive Neck, Amer J Surg,November 1994; 168:499-502.
- 7. Rassekh, Christopher H., Accuracy of Intraoperative Staging of the N0 Neck in Squamous Cell Carcinoma, Laryngoscope, December 1995; 105:1334-1336.
- 8. Friedman, Michael, Rationale for Elective Neck Dissection in 1990, Laryngoscope,January 1990; 100:54-59.
- 9. Shah, Jatin P., Patterns of Cervical Lymph Node Metastasis from Squamous Carcinomas of the Upper Aerodigestive Tract, Amer J Surg, October 1990; 160:405-409.
- 10. Shah, Jatin P., The Patterns of Cervical Lymph Node Metastases From Squamous Carcinoma of the Oral Cavity, Cancer, July 1, 1990; 109-113.
- Patient Information for neck dissection at Georgetown Univ. Hospital[dead link]
- Neck dissection: an operation in evolution in World Journal of Surgical Oncology - 8 references
- eMedicine: Head and Neck Cancer: Resection and Neck Dissection - with diagram of levels 1-5
- eMedicine: Radical Neck Dissection - inc image showing neck structures