Netrin 1
Netrin-1 is a protein that in humans is encoded by the NTN1 gene.[5][6]
Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest that variation in netrin may be involved in cancer development.[6]
Interactions
NTN1 has been shown to interact with Deleted in Colorectal Cancer.[5][7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000065320 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020902 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b Meyerhardt JA, Caca K, Eckstrand BC, Hu G, Lengauer C, Banavali S, Look AT, Fearon ER (Apr 1999). "Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas". Cell Growth Differ. 10 (1): 35–42. PMID 9950216.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ a b "Entrez Gene: NTN1 netrin 1".
- ^ Geisbrecht, Brian V; Dowd Kimberly A; Barfield Ronald W; Longo Patti A; Leahy Daniel J (Aug 2003). "Netrin binds discrete subdomains of DCC and UNC5 and mediates interactions between DCC and heparin". J. Biol. Chem. 278 (35). United States: 32561–8. doi:10.1074/jbc.M302943200. ISSN 0021-9258. PMID 12810718.
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Further reading
External links
- NTN1 human gene location in the UCSC Genome Browser.
- NTN1 human gene details in the UCSC Genome Browser.
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