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  (Redirected from Neurexin 1)
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Protein NRXN1 PDB 1c4r.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesNRXN1, Hs.22998, PTHSL2, SCZD17, neurexin 1
External IDsMGI: 1096391 HomoloGene: 21005 GeneCards: NRXN1
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for NRXN1
Genomic location for NRXN1
Band2p16.3Start49,918,503 bp[1]
End51,225,575 bp[1]
RNA expression pattern
PBB GE NRXN1 209915 s at fs.png

PBB GE NRXN1 209914 s at fs.png

PBB GE NRXN1 216096 s at fs.png
More reference expression data
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 2: 49.92 – 51.23 MbChr 17: 90.03 – 91.09 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Neurexin-1-alpha is a protein that in humans is encoded by the NRXN1 gene.[5]

Neurexins are a family of proteins that function in the vertebrate nervous system as cell adhesion molecules and receptors. They are encoded by several unlinked genes of which two, NRXN1 and NRXN3, are among the largest known human genes. Three of the genes (NRXN1-3) utilize two alternate promoters and include numerous alternatively spliced exons to generate thousands of distinct mRNA transcripts and protein isoforms. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms; a much smaller number of transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins.[5]


The gene is found in a single copy on the short arm of chromosome 2 (2p16.3). The gene is 1,112,187 bases in length, is located on the Crick (minus) strand and encodes a protein of 1,477 amino acids (molecular weight 161.883 kDa).

Mutations of this gene that interrupt its expression have been associated with schizophrenia, autism, and intellectual disability (NRXN1 mutations and brain disorders).


NRXN1 has been shown to interact with NLGN1.[6][7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000179915 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024109 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ a b "Entrez Gene: NRXN1 neurexin 1".
  6. ^ Comoletti, Davide; Flynn Robyn; Jennings Lori L; Chubykin Alexander; Matsumura Takehito; Hasegawa Hana; Südhof Thomas C; Taylor Palmer (Dec 2003). "Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta". J. Biol. Chem. United States. 278 (50): 50497–50505. doi:10.1074/jbc.M306803200. ISSN 0021-9258. PMID 14522992.
  7. ^ Ichtchenko, K; Nguyen T; Südhof T C (Feb 1996). "Structures, alternative splicing, and neurexin binding of multiple neuroligins". J. Biol. Chem. UNITED STATES. 271 (5): 2676–2682. doi:10.1074/jbc.271.5.2676. ISSN 0021-9258. PMID 8576240.

Further reading[edit]