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OAE could refer to:
- Oceanic Anoxic event, in which the Earth's oceans become completely depleted of oxygen below the surface levels.
- Orchestra of the Age of Enlightenment, a British period instrument orchestra.
- Otoacoustic emissions, involved in testing hearing.
- Omni Air Express, United States (ICAO operator designator)
- Overall Asset Effectiveness
- Overall Acquisition Engine
- Operation Active Endeavour
- Oddworld: Abe's Exoddus a platform game made by Oddworld Inhabitants released in 1998.
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