OAS3

OAS3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4S3N
Identifiers
Aliases	OAS3, p100, p100OAS, 2'-5'-oligoadenylate synthetase 3
External IDs	OMIM: 603351; MGI: 2180850; HomoloGene: 4510; GeneCards: OAS3; OMA:OAS3 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	112,976,460 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	120,915,726 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; decidua; ; gallbladder; ; apex of heart; ; mucosa of esophagus; ; appendix; ; bone marrow cells; ; oral cavity; ; epithelium of colon;
	Top expressed in
	granulocyte; ; blood; ; mucous cell of stomach; ; intestinal villus; ; jejunum; ; bone marrow; ; stroma of bone marrow; ; zygote; ; thymus; ; spleen;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; nucleotidyltransferase activity; metal ion binding; 2'-5'-oligoadenylate synthetase activity; protein binding; RNA binding; double-stranded RNA binding; ATP binding;
Cellular component	cytoplasm; intracellular membrane-bounded organelle; plasma membrane; nucleoplasm; nucleus; extracellular space; cytosol;
Biological process	regulation of ribonuclease activity; immune system process; interferon-gamma-mediated signaling pathway; response to virus; negative regulation of viral genome replication; defense response to virus; type I interferon signaling pathway; immune response; innate immune response; nucleobase-containing compound metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	4940
	246727
	ENSG00000111331
	ENSMUSG00000032661
	Q9Y6K5
	Q8VI93
	NM_006187
	NM_145226
	NP_006178
	NP_660261
	Wikidata
View/Edit Human	View/Edit Mouse

2'-5'-oligoadenylate synthetase 3 is an enzyme that in humans is encoded by the OAS3 gene.^[5]^[6]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000111331 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032661 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hovnanian A, Rebouillat D, Mattei MG, Levy ER, Marie I, Monaco AP, Hovanessian AG (Dec 1998). "The human 2',5'-oligoadenylate synthetase locus is composed of three distinct genes clustered on chromosome 12q24.2 encoding the 100-, 69-, and 40-kDa forms". Genomics. 52 (3): 267–77. doi:10.1006/geno.1998.5443. PMID 9790745.
^ "Entrez Gene: OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa".

References

Further reading