Orotidine 5'-monophosphate

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Orotidine 5'-monophosphate
Orotidine monophosphate.svg
Names
IUPAC name
3-[(2R,3R,4S,5R)-3,4-dihydroxy-5-​(phosphonooxymethyl)oxolan-2-yl]​-2,6-dioxo-pyrimidine-4-carboxylic acid
Other names
Orotidylic acid,
OMP
Identifiers
3D model (JSmol)
ChemSpider
MeSH Orotidine+5'-monophosphate
Properties
C10H13N2O11P
Molar mass 368.191 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Orotidine 5'-monophosphate (OMP), also known as orotidylic acid, is a pyrimidine nucleotide which is the last intermediate in the biosynthesis of uridine monophosphate. OMP is formed from orotate and phosphoribosyl pyrophosphate by the enzyme orotate phosphoribosyltransferase

In humans, the enzyme UMP synthase converts OMP into uridine 5'- monophosphate. If UMP synthase is defective, orotic aciduria can result.