Osler's node

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Not to be confused with Janeway lesion.
Osler's lesions found on the hand and fingers of a 43-year-old male with subacute bacterial endocarditis.

Osler's nodes are painful, red, raised lesions found on the hands and feet. They are associated with a number of conditions, including infective endocarditis, and are caused by immune complex deposition. They are named after Sir William Osler who described them in the early 20th century.[1][2] Their presence is one definition of Osler's sign.[3]


Osler's nodes result from the deposition of immune complexes.[4] The resulting inflammatory response leads to swelling, redness, and pain that characterize these lesions.

The nodes are commonly indicative of subacute bacterial endocarditis.[5] 10–25% of endocarditis patients will have Osler's nodes.[citation needed] Other signs of endocarditis include Roth's spots and Janeway lesions. The latter, which also occur on the palms and soles, can be differentiated from Osler's nodes because they are nontender.[4]

It can also be seen in

External links[edit]


  1. ^ synd/1702 at Who Named It?
  2. ^ Osler, W (1908–1909). "Chronic infectious endocarditis". Quarterly Journal of Medicine (Oxford) 2: 219–230. 
  3. ^ "Osler sign" at Dorland's Medical Dictionary
  4. ^ a b Farrior, JB; Silverman, ME (August 1976). "A consideration of the differences between a Janeway's lesion and an Osler's node in infectious endocarditis" (PDF). Chest 70 (2): 239–43. doi:10.1378/chest.70.2.239. PMID 947688. 
  5. ^ "Osler nodes" at Dorland's Medical Dictionary