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He is a lawyer. From 1975 to 1979 he was chief of the youth organization Jungen Union Bayern. Since 1974 he has been a member of the Bavarian Parliament. Since July 17, 1993 he has been Bavarian minister for traffic and the economy.
On May 7, 2004 he was elected president of the Deutsch-Arabische Gesellschaft
On October 29, 1983 he was driving his Mercedes 380 while drunk (1.75 promille) and killed Polish citizen Josef Rubinfeld in his Fiat and severely injured another man. Otto Wiesheu was given 12 months' probation.
- Yŏnhap Tʻongsin (2003). North Korea handbook. M.E. Sharpe. p. 350. ISBN 978-0-7656-1004-1. Retrieved 26 April 2011.
- Bauchmüller, M.; M. Beise; K. Ott (13 May 2009). "Bahn: Otto Wiesheu - Lobbyist ohne Fahrschein". Süddeutsche Zeitung (in German). Retrieved 26 April 2011.
- Ardagh, John (1988-09-01). Germany and the Germans: an anatomy of society today. Harper & Row. p. 417. ISBN 978-0-06-091532-2. Retrieved 26 April 2011.
- Rambow, Kristen-Eirin. ... Und Weihnachten Liegt In Afrika. BoD – Books on Demand. p. 49. ISBN 978-3-8423-4412-9. Retrieved 26 April 2011.