P4HA1

P4HA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1TJC, 2V5F, 2YQ8, 4BT8, 4BT9, 4BTA, 4BTB
Identifiers
Aliases	P4HA1, P4HA, prolyl 4-hydroxylase subunit alpha 1
External IDs	OMIM: 176710; MGI: 97463; HomoloGene: 30998; GeneCards: P4HA1; OMA:P4HA1 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	73,096,974 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	59,209,126 bp
RNA expression pattern
	Top expressed in
	cartilage tissue; ; Achilles tendon; ; tibia; ; ventricular zone; ; pericardium; ; stromal cell of endometrium; ; periodontal fiber; ; gastrocnemius muscle; ; tibialis anterior muscle; ; triceps brachii muscle;
	Top expressed in
	calvaria; ; epithelium of lens; ; stroma of bone marrow; ; right lung lobe; ; dermis; ; body of femur; ; cumulus cell; ; sciatic nerve; ; yolk sac; ; umbilical cord;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	iron ion binding; L-ascorbic acid binding; oxidoreductase activity; protein binding; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; dioxygenase activity; procollagen-proline 4-dioxygenase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; metal ion binding; identical protein binding;
Cellular component	procollagen-proline 4-dioxygenase complex; endoplasmic reticulum; mitochondrion; membrane; intracellular membrane-bounded organelle; endoplasmic reticulum lumen;
Biological process	peptidyl-proline hydroxylation to 4-hydroxy-L-proline; collagen fibril organization;
	Sources:Amigo / QuickGO
Orthologs
	5033
	18451
	ENSG00000122884
	ENSMUSG00000019916
	P13674
	Q60715
	NM_001142596; NM_000917; NM_001017962; NM_001142595
	NM_011030; NM_001316370; NM_001316371
	NP_000908; NP_001017962; NP_001136067; NP_001136068
	NP_001303299; NP_001303300; NP_035160
	Wikidata
View/Edit Human	View/Edit Mouse

Prolyl 4-hydroxylase subunit alpha-1 is an enzyme that in humans is encoded by the P4HA1 gene.^[5]^[6]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000122884 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019916 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Pajunen L, Jones TA, Helaakoski T, Pihlajaniemi T, Solomon E, Sheer D, Kivirikko KI (Jan 1990). "Assignment of the gene coding for the alpha-subunit of prolyl 4-hydroxylase to human chromosome region 10q21.3-23.1". Am J Hum Genet. 45 (6): 829–34. PMC 1683466. PMID 2556027.
^ "Entrez Gene: P4HA1 procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide I".

References

Further reading