Parkin coregulated gene protein is a protein that in humans is encoded by the PACRGgene.
This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene.
Schurr E, Alcaïs A, de Léséleuc L, Abel L (2006). "Genetic predisposition to leprosy: A major gene reveals novel pathways of immunity to Mycobacterium leprae". Semin. Immunol.18 (6): 404–10. doi:10.1016/j.smim.2006.07.005. PMID16973374.
Mira MT, Alcaïs A, Van Thuc N, et al. (2003). "Chromosome 6q25 is linked to susceptibility to leprosy in a Vietnamese population". Nat. Genet.33 (3): 412–5. doi:10.1038/ng1096. PMID12577057.
Imai Y, Soda M, Murakami T, et al. (2004). "A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death". J. Biol. Chem.278 (51): 51901–10. doi:10.1074/jbc.M309655200. PMID14532270.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet.36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
Mira MT, Alcaïs A, Nguyen VT, et al. (2004). "Susceptibility to leprosy is associated with PARK2 and PACRG". Nature427 (6975): 636–40. doi:10.1038/nature02326. PMID14737177.
Lockhart PJ, O'Farrell CA, Farrer MJ (2004). "It's a double knock-out! The quaking mouse is a spontaneous deletion of parkin and parkin co-regulated gene (PACRG)". Mov. Disord.19 (1): 101–4. doi:10.1002/mds.20000. PMID14743368.
Agirre X, Román-Gómez J, Vázquez I, et al. (2006). "Abnormal methylation of the common PARK2 and PACRG promoter is associated with downregulation of gene expression in acute lymphoblastic leukemia and chronic myeloid leukemia". Int. J. Cancer118 (8): 1945–53. doi:10.1002/ijc.21584. PMID16287063.
Malhotra D, Darvishi K, Lohra M, et al. (2006). "Association study of major risk single nucleotide polymorphisms in the common regulatory region of PARK2 and PACRG genes with leprosy in an Indian population". Eur. J. Hum. Genet.14 (4): 438–42. doi:10.1038/sj.ejhg.5201563. PMID16391553.
Lesage S, Magali P, Lohmann E, et al. (2007). "Deletion of the parkin and PACRG gene promoter in early-onset parkinsonism". Hum. Mutat.28 (1): 27–32. doi:10.1002/humu.20436. PMID17068781.
Taylor JM, Song YJ, Huang Y, et al. (2007). "Parkin Co-Regulated Gene (PACRG) is regulated by the ubiquitin-proteasomal system and is present in the pathological features of Parkinsonian diseases". Neurobiol. Dis.27 (2): 238–47. doi:10.1016/j.nbd.2007.04.014. PMID17590346.
Udina IG, Kordicheva SIu, Pospelov LE, et al. (2007). "[Study of the polymorphic markers--the PARK2 and PACRG genes due to the incidence of pulmonary tuberculosis in two districts of the Republic of Tyva]". Problemy tuberkuleza i bolezneĭ legkikh (7): 27–9. PMID17722288.