PACRG

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PACRG
Identifiers
Aliases PACRG, GLUP, HAK005771, PARK2CRG, PARK2 co-regulated
External IDs MGI: 1916560 HomoloGene: 16212 GeneCards: 135138
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001080378
NM_001080379
NM_152410

NM_027032

RefSeq (protein)

NP_001073847.1
NP_001073848.1
NP_689623.2

NP_081308.1

Location (UCSC) Chr 6: 162.73 – 163.32 Mb Chr 17: 10.4 – 10.84 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Parkin coregulated gene protein is a protein that in humans is encoded by the PACRG gene.[1][2]

This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene.[2]

References[edit]

  1. ^ West AB, Lockhart PJ, O'Farell C, Farrer MJ (Jan 2003). "Identification of a novel gene linked to parkin via a bi-directional promoter". J Mol Biol 326 (1): 11–9. doi:10.1016/S0022-2836(02)01376-1. PMID 12547187. 
  2. ^ a b "Entrez Gene: PACRG PARK2 co-regulated". 

Further reading[edit]