PADI2

PADI2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4N20, 4N22, 4N24, 4N25, 4N26, 4N28, 4N2A, 4N2B, 4N2C, 4N2D, 4N2E, 4N2F, 4N2G, 4N2H, 4N2I, 4N2K, 4N2L, 4N2M, 4N2N
Identifiers
Aliases	PADI2, PAD-H19, PAD2, PDI2, peptidyl arginine deiminase 2
External IDs	OMIM: 607935; MGI: 1338892; HomoloGene: 7214; GeneCards: PADI2; OMA:PADI2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	17,119,451 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	140,679,897 bp
RNA expression pattern
	Top expressed in
	internal globus pallidus; ; inferior olivary nucleus; ; inferior ganglion of vagus nerve; ; middle frontal gyrus; ; external globus pallidus; ; subthalamic nucleus; ; gastrocnemius muscle; ; tibialis anterior muscle; ; optic nerve; ; ventral tegmental area;
	Top expressed in
	saccule; ; lacrimal gland; ; digastric muscle; ; retinal pigment epithelium; ; sternocleidomastoid muscle; ; stria vascularis; ; triceps brachii muscle; ; ankle; ; vastus lateralis muscle; ; utricle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; estrogen receptor binding; hydrolase activity; protein-arginine deiminase activity; protein homodimerization activity; metal ion binding;
Cellular component	extracellular exosome; cytoplasm; cytosol; extracellular region; nucleus; azurophil granule lumen;
Biological process	negative regulation of chemokine-mediated signaling pathway; substantia nigra development; intracellular estrogen receptor signaling pathway; negative regulation of lymphocyte chemotaxis; chromatin organization; neutrophil degranulation; cellular response to leukemia inhibitory factor;
	Sources:Amigo / QuickGO
Orthologs
	11240
	18600
	ENSG00000117115
	ENSMUSG00000028927
	Q9Y2J8
	Q08642
	NM_007365
	NM_008812
	NP_031391
	NP_032838
	Wikidata
View/Edit Human	View/Edit Mouse

Protein-arginine deiminase type-2 is an enzyme that in humans is encoded by the PADI2 gene.^[5]^[6]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000117115 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028927 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Watanabe K, Senshu T (Oct 1989). "Isolation and characterization of cDNA clones encoding rat skeletal muscle peptidylarginine deiminase". J Biol Chem. 264 (26): 15255–60. PMID 2768262.
^ "Entrez Gene: PADI2 peptidyl arginine deiminase, type II".

References

Further reading