PAG1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
PAG1
Identifiers
Aliases PAG1, CBP, PAG, phosphoprotein membrane anchor with glycosphingolipid microdomains 1
External IDs MGI: 2443160 HomoloGene: 10198 GeneCards: PAG1
RNA expression pattern
PBB GE PAG1 gnf1h00294 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_018440

NM_001195031
NM_053182

RefSeq (protein)

NP_060910

NP_001181960.1
NP_444412.2
NP_001181960
NP_444412

Location (UCSC) Chr 8: 80.97 – 81.11 Mb Chr 3: 9.69 – 9.83 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 is a protein that in humans is encoded by the PAG1 gene.[3][4]

The protein encoded by this gene is a type III transmembrane adaptor protein that binds to the tyrosine kinase csk protein. It is thought to be involved in the regulation of T cell activation.[4]

Interactions[edit]

PAG1 has been shown to interact with FYN,[3] C-src tyrosine kinase,[3] Sodium-hydrogen antiporter 3 regulator 1[5] and Abl gene.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b c Brdicka T, Pavlistova D, Leo A, Bruyns E, Korinek V, Angelisova P, Scherer J, Shevchenko A, Hilgert I, Cerny J, Drbal K, Kuramitsu Y, Kornacker B, Horejsi V, Schraven B (May 2000). "Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation". J Exp Med. 191 (9): 1591–604. doi:10.1084/jem.191.9.1591. PMC 2213442Freely accessible. PMID 10790433. 
  4. ^ a b "Entrez Gene: PAG1 phosphoprotein associated with glycosphingolipid microdomains 1". 
  5. ^ Brdicková, N; Brdicka T; Andera L; Spicka J; Angelisová P; Milgram S L; Horejsí V (Oct 2001). "Interaction between two adapter proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeleton". FEBS Lett. Netherlands. 507 (2): 133–6. doi:10.1016/S0014-5793(01)02955-6. ISSN 0014-5793. PMID 11684085. 
  6. ^ Wen, S T; Van Etten R A (Oct 1997). "The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity". Genes Dev. UNITED STATES. 11 (19): 2456–67. doi:10.1101/gad.11.19.2456. ISSN 0890-9369. PMC 316562Freely accessible. PMID 9334312. 

Further reading[edit]