PARC (gene)

CUL9
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2JUF
Identifiers
Aliases	CUL9, H7AP1, PARC, 1810035I07Rik, Cul-9, mKIAA0708, cullin 9
External IDs	OMIM: 607489; MGI: 1925559; HomoloGene: 56696; GeneCards: CUL9; OMA:CUL9 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	43,224,587 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	46,857,314 bp
RNA expression pattern
	Top expressed in
	right testis; ; left testis; ; right frontal lobe; ; right hemisphere of cerebellum; ; anterior pituitary; ; granulocyte; ; right lobe of thyroid gland; ; skin of abdomen; ; skin of leg; ; spleen;
	Top expressed in
	neural layer of retina; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; superior frontal gyrus; ; muscle of thigh; ; spermatocyte; ; right kidney; ; cerebellar cortex; ; proximal tubule; ; lumbar subsegment of spinal cord;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; protein binding; ATP binding; ubiquitin protein ligase binding; metal ion binding; transferase activity;
Cellular component	cytoplasm; cullin-RING ubiquitin ligase complex; cytosol;
Biological process	microtubule cytoskeleton organization; ubiquitin-dependent protein catabolic process; regulation of mitotic nuclear division; protein ubiquitination; post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologs
	23113
	78309
	ENSG00000112659
	ENSMUSG00000040327
	Q8IWT3
	Q80TT8
	NM_015089
	NM_001081335
	NP_055904
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Cullin-9 is a protein that in humans is encoded by the CUL9 gene.^[5]^[6]^[7]^[8]

Template:PBB Summary

Interactions

PARC (gene) has been shown to interact with P53.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112659 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040327 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Skaar JR, Florens L, Tsutsumi T, Arai T, Tron A, Swanson SK, Washburn MP, DeCaprio JA (Mar 2007). "PARC and CUL7 form atypical cullin RING ligase complexes". Cancer Res. 67 (5): 2006–14. doi:10.1158/0008-5472.CAN-06-3241. PMID 17332328.
^ Moynihan TP, Ardley HC, Nuber U, Rose SA, Jones PF, Markham AF, Scheffner M, Robinson PA (Nov 1999). "The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1". J Biol Chem. 274 (43): 30963–8. doi:10.1074/jbc.274.43.30963. PMID 10521492.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ ^a ^b Nikolaev AY, Li M, Puskas N, Qin J, Gu W (Jan 2003). "Parc: a cytoplasmic anchor for p53". Cell. 112 (1): 29–40. doi:10.1016/S0092-8674(02)01255-2. PMID 12526791.
^ "Entrez Gene: PARC p53-associated parkin-like cytoplasmic protein".

Interactions

References

Further reading