PDE11A

PDE11A
Identifiers
Aliases	PDE11A, PPNAD2, phosphodiesterase 11A
External IDs	OMIM: 604961; MGI: 3036251; HomoloGene: 56763; GeneCards: PDE11A; OMA:PDE11A - orthologs
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	76,169,118 bp
RNA expression pattern
	Top expressed in
	deltoid muscle; ; quadriceps femoris muscle; ; vastus lateralis muscle; ; liver; ; gastrocnemius muscle; ; prostate; ; biceps brachii; ; right lobe of liver; ; tibialis anterior muscle; ; tibia;
	Top expressed in
	hippocampus proper; ; dentate gyrus of hippocampal formation granule cell; ; embryo; ; ileum; ; primary visual cortex; ; midbrain tegmentum; ; jejunum; ; Cortex of frontal lobe; ; white adipose tissue; ; cerebellar cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphoric diester hydrolase activity; catalytic activity; 3',5'-cyclic-nucleotide phosphodiesterase activity; hydrolase activity; metal ion binding; cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; 3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-GMP phosphodiesterase activity; cyclic-nucleotide phosphodiesterase activity; cGMP binding;
Cellular component	cytoplasm; cytosol; cellular component;
Biological process	metabolism; signal transduction; G protein-coupled receptor signaling pathway; negative regulation of cGMP-mediated signaling; negative regulation of cAMP-mediated signaling;
	Sources:Amigo / QuickGO
Orthologs
	50940
	241489
	n/a
	ENSMUSG00000075270
	Q9HCR9
	P0C1Q2
	NM_016953; NM_001077196; NM_001077197; NM_001077358
	NM_001081033
	NP_001070664; NP_001070665; NP_001070826; NP_058649
	NP_001074502
	Wikidata
View/Edit Human	View/Edit Mouse

Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A is an enzyme that in humans is encoded by the PDE11A gene.^[4]^[5]

Template:PBB Summary

Inhibitors

BC11-38 ^[6]

References

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000075270 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Fawcett L, Baxendale R, Stacey P, McGrouther C, Harrow I, Soderling S, Hetman J, Beavo JA, Phillips SC (Apr 2000). "Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A". Proc Natl Acad Sci U S A. 97 (7): 3702–7. doi:10.1073/pnas.050585197. PMC 16303. PMID 10725373.
^ "Entrez Gene: PDE11A phosphodiesterase 11A".
^ Ceyhan O, Birsoy K, Hoffman CS (2012). "Identification of biologically active PDE11-selective inhibitors using a yeast-based high-throughput screen". Chem. Biol. 19 (1): 155–63. doi:10.1016/j.chembiol.2011.12.010. PMID 22284362.

Inhibitors

References

Further reading