PDXK

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PDXK
Protein PDXK PDB 2ajp.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPDXK, C21orf124, C21orf97, HEL-S-1a, PKH, PNK, PRED79, pyridoxal (pyridoxine, vitamin B6) kinase, pyridoxal kinase, HMSN6C
External IDsOMIM: 179020 MGI: 1351869 HomoloGene: 2731 GeneCards: PDXK
Gene location (Human)
Chromosome 21 (human)
Chr.Chromosome 21 (human)[1]
Chromosome 21 (human)
Genomic location for PDXK
Genomic location for PDXK
Band21q22.3Start43,719,094 bp[1]
End43,762,307 bp[1]
RNA expression pattern
PBB GE PDXK 202671 s at fs.png

PBB GE PDXK 218019 s at fs.png

PBB GE PDXK 218018 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003681
NM_021941
NM_001331030

NM_172134

RefSeq (protein)

NP_001317959
NP_003672

NP_742146

Location (UCSC)Chr 21: 43.72 – 43.76 MbChr 10: 78.44 – 78.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Pyridoxal kinase is an enzyme that in humans is encoded by the PDXK gene.[5][6]

The protein encoded by this gene phosphorylates vitamin B6, a step required for the conversion of vitamin B6 to pyridoxal-5-phosphate, an important cofactor in intermediary metabolism. The encoded protein is cytoplasmic and probably acts as a homodimer. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000160209 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032788 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hanna MC, Turner AJ, Kirkness EF (May 1997). "Human pyridoxal kinase. cDNA cloning, expression, and modulation by ligands of the benzodiazepine receptor". J Biol Chem. 272 (16): 10756–60. doi:10.1074/jbc.272.16.10756. PMID 9099727.
  6. ^ a b "Entrez Gene: PDXK pyridoxal (pyridoxine, vitamin B6) kinase".

Further reading[edit]