PIGU

PIGU
Identifiers
Aliases	PIGU, CDC91L1, GAB1, phosphatidylinositol glycan anchor biosynthesis class U, GPIBD21, NEDBSS
External IDs	OMIM: 608528; MGI: 3039607; HomoloGene: 6553; GeneCards: PIGU; OMA:PIGU - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	34,698,790 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	155,199,350 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; ganglionic eminence; ; ventricular zone; ; islet of Langerhans; ; C1 segment; ; oocyte; ; tibialis anterior muscle; ; gonad; ; rectum; ; right uterine tube;
	Top expressed in
	external carotid artery; ; internal carotid artery; ; genital tubercle; ; tail of embryo; ; muscle of thigh; ; yolk sac; ; right kidney; ; proximal tubule; ; conjunctival fornix; ; primary oocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	GPI-anchor transamidase activity; GPI anchor binding;
Cellular component	integral component of membrane; integral component of endoplasmic reticulum membrane; plasma membrane; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; GPI-anchor transamidase complex;
Biological process	GPI anchor biosynthetic process; regulation of receptor signaling pathway via JAK-STAT; attachment of GPI anchor to protein; protein localization to cell surface;
	Sources:Amigo / QuickGO
Orthologs
	128869
	228812
	ENSG00000101464
	ENSMUSG00000038383
	Q9H490
	Q3TAA8
	NM_080476
	NM_001004721
	NP_536724
	NP_001004721
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphatidylinositol glycan anchor biosynthesis class U protein is a protein that in humans is encoded by the PIGU gene.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000101464 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038383 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hong Y, Ohishi K, Kang JY, Tanaka S, Inoue N, Nishimura J, Maeda Y, Kinoshita T (Jun 2003). "Human PIG-U and yeast Cdc91p are the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins". Mol Biol Cell. 14 (5): 1780–9. doi:10.1091/mbc.E02-12-0794. PMC 165076. PMID 12802054.
^ Guo Z, Linn JF, Wu G, Anzick SL, Eisenberger CF, Halachmi S, Cohen Y, Fomenkov A, Hoque MO, Okami K, Steiner G, Engles JM, Osada M, Moon C, Ratovitski E, Trent JM, Meltzer PS, Westra WH, Kiemeney LA, Schoenberg MP, Sidransky D, Trink B (Apr 2004). "CDC91L1 (PIG-U) is a newly discovered oncogene in human bladder cancer". Nat Med. 10 (4): 374–81. doi:10.1038/nm1010. PMID 15034568.
^ "Entrez Gene: PIGU phosphatidylinositol glycan anchor biosynthesis, class U".