PLD5

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PLD5
Identifiers
Aliases PLD5, PLDC, phospholipase D family member 5
External IDs MGI: 2442056 HomoloGene: 16081 GeneCards: PLD5
Genetically Related Diseases
coronary artery disease[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001195811
NM_001195812
NM_152666
NM_001320272

NM_001195816
NM_176916

RefSeq (protein)

NP_001182740
NP_001182741
NP_001307201
NP_689879

NP_001182745.1
NP_795890.2
NP_001182745
NP_795890

Location (UCSC) Chr 1: 242.08 – 242.52 Mb Chr 1: 175.96 – 176.28 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Phospholipase D family, member 5 is a protein that in humans is encoded by the PLD5 gene.[4]

Model organisms[edit]

Model organisms have been used in the study of PLD5 function. A conditional knockout mouse line, called Pld5tm1a(KOMP)Wtsi[9][10] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute.[11][12][13]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[7][14] Twenty five tests were carried out on mutant mice but no significant abnormalities were observed.[7]

References[edit]

  1. ^ "Diseases that are genetically associated with PLD5 view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ "Entrez Gene: PLD5 phospholipase D family, member 5". Retrieved 2011-12-04. 
  5. ^ "Salmonella infection data for Pld5". Wellcome Trust Sanger Institute. 
  6. ^ "Citrobacter infection data for Pld5". Wellcome Trust Sanger Institute. 
  7. ^ a b c Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88 (S248). doi:10.1111/j.1755-3768.2010.4142.x. 
  8. ^ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  9. ^ "International Knockout Mouse Consortium". 
  10. ^ "Mouse Genome Informatics". 
  11. ^ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–342. doi:10.1038/nature10163. PMC 3572410Freely accessible. PMID 21677750. 
  12. ^ Dolgin E (June 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718. 
  13. ^ Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. 
  14. ^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837Freely accessible. PMID 21722353. 

Further reading[edit]