Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). The C-terminal 570 amino acids of the T-plastin and L-plastin proteins are 83% identical. It contains a potential calcium-binding site near the N-terminus.
Goldstein D, Djeu J, Latter G et al. (1985). "Abundant synthesis of the transformation-induced protein of neoplastic human fibroblasts, plastin, in normal lymphocytes.". Cancer Res.45 (11 Pt 2): 5643–7. PMID4053036.
Goldsmith SC, Pokala N, Shen W et al. (1997). "The structure of an actin-crosslinking domain from human fimbrin.". Nat. Struct. Biol.4 (9): 708–12. doi:10.1038/nsb0997-708. PMID9302997.
Shoeman RL, Hartig R, Hauses C, Traub P (2003). "Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease.". Cell Biol. Int.26 (6): 529–39. doi:10.1006/cbir.2002.0895. PMID12119179.
Su MW, Dorocicz I, Dragowska WH et al. (2004). "Aberrant expression of T-plastin in Sezary cells.". Cancer Res.63 (21): 7122–7. PMID14612505.
Giganti A, Plastino J, Janji B et al. (2005). "Actin-filament cross-linking protein T-plastin increases Arp2/3-mediated actin-based movement.". J. Cell. Sci.118 (Pt 6): 1255–65. doi:10.1242/jcs.01698. PMID15741236.
Ralser M, Nonhoff U, Albrecht M et al. (2005). "Ataxin-2 and huntingtin interact with endophilin-A complexes to function in plastin-associated pathways.". Hum. Mol. Genet.14 (19): 2893–909. doi:10.1093/hmg/ddi321. PMID16115810.
Ikeda H, Sasaki Y, Kobayashi T et al. (2006). "The role of T-fimbrin in the response to DNA damage: silencing of T-fimbrin by small interfering RNA sensitizes human liver cancer cells to DNA-damaging agents.". Int. J. Oncol.27 (4): 933–40. doi:10.3892/ijo.27.4.933. PMID16142308.