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Plastin 3
Protein PLS3 PDB 1aoa.png
PDB rendering based on 1aoa.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PLS3 ; BMND18; T-plastin
External IDs OMIM300131 MGI104807 HomoloGene128200 GeneCards: PLS3 Gene
RNA expression pattern
PBB GE PLS3 201215 at tn.png
More reference expression data
Species Human Mouse
Entrez 5358 102866
Ensembl ENSG00000102024 ENSMUSG00000016382
UniProt P13797 Q99K51
RefSeq (mRNA) NM_001136025 NM_001166453
RefSeq (protein) NP_001129497 NP_001159925
Location (UCSC) Chr X:
115.56 – 115.65 Mb
Chr X:
75.79 – 75.88 Mb
PubMed search [1] [2]

Plastin-3 is a highly conserved protein that in humans is encoded by the PLS3 gene on the X chromosome.[1][2]


Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). The C-terminal 570 amino acids of the T-plastin and L-plastin proteins are 83% identical. It contains a potential calcium-binding site near the N-terminus.[2]

Clinical significance[edit]

Defects in PLS3 are associated with osteoporosis and bone fracture in humans and in knockout zebrafish.[3]


  1. ^ Lin CS, Park T, Chen ZP, Leavitt J (Mar 1993). "Human plastin genes. Comparative gene structure, chromosome location, and differential expression in normal and neoplastic cells". J Biol Chem 268 (4): 2781–92. PMID 8428952. 
  2. ^ a b "Entrez Gene: PLS3 plastin 3 (T isoform)". 
  3. ^ van Dijk FS, Zillikens MC, Micha D, Riessland M, Marcelis CL, de Die-Smulders CE, Milbradt J, Franken AA, Harsevoort AJ, Lichtenbelt KD; et al. (October 2013). "PLS3 Mutations in X-Linked Osteoporosis with Fractures". N. Engl. J. Med. 369 (16): 1529–36. doi:10.1056/NEJMoa1308223. PMID 24088043. 

Further reading[edit]