POLE3

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POLE3
Identifiers
AliasesPOLE3, CHARAC17, CHRAC17, YBL1, p17, polymerase (DNA) epsilon 3, accessory subunit, DNA polymerase epsilon 3, accessory subunit
External IDsMGI: 1933378 HomoloGene: 9694 GeneCards: POLE3
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for POLE3
Genomic location for POLE3
Band9q32Start113,407,235 bp[1]
End113,410,672 bp[1]
RNA expression pattern
PBB GE POLE3 208828 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001278255
NM_017443

NM_021498

RefSeq (protein)

NP_001265184
NP_059139

NP_067473

Location (UCSC)Chr 9: 113.41 – 113.41 MbChr 4: 62.52 – 62.53 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

DNA polymerase epsilon subunit 3 is an enzyme that in humans is encoded by the POLE3 gene.[5][6][7]

POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM][7]

Interactions[edit]

POLE3 has been shown to interact with SMARCA5.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000148229 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028394 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Li Y, Pursell ZF, Linn S (Aug 2000). "Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon". J Biol Chem. 275 (30): 23247–52. doi:10.1074/jbc.M002548200. PMID 10801849. 
  6. ^ a b Poot RA, Dellaire G, Hulsmann BB, Grimaldi MA, Corona DF, Becker PB, Bickmore WA, Varga-Weisz PD (Oct 2000). "HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins". EMBO J. 19 (13): 3377–87. doi:10.1093/emboj/19.13.3377. PMC 313940Freely accessible. PMID 10880450. 
  7. ^ a b "Entrez Gene: POLE3 polymerase (DNA directed), epsilon 3 (p17 subunit)". 

Further reading[edit]