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Polymerase (DNA directed), epsilon 3, accessory subunit
Symbols POLE3 ; CHARAC17; CHRAC17; YBL1; p17
External IDs OMIM607267 MGI1933378 HomoloGene9694 GeneCards: POLE3 Gene
EC number
RNA expression pattern
PBB GE POLE3 208828 at tn.png
More reference expression data
Species Human Mouse
Entrez 54107 59001
Ensembl ENSG00000148229 ENSMUSG00000028394
UniProt Q9NRF9 Q9JKP7
RefSeq (mRNA) NM_001278255 NM_021498
RefSeq (protein) NP_001265184 NP_067473
Location (UCSC) Chr 9:
113.41 – 113.41 Mb
Chr 4:
62.52 – 62.53 Mb
PubMed search [1] [2]

DNA polymerase epsilon subunit 3 is an enzyme that in humans is encoded by the POLE3 gene.[1][2][3]

POLE3 is a histone-fold protein that interacts with other histone-fold proteins to bind DNA in a sequence-independent manner. These histone-fold protein dimers combine within larger enzymatic complexes for DNA transcription, replication, and packaging.[supplied by OMIM][3]


POLE3 has been shown to interact with SMARCA5.[2]


  1. ^ Li Y, Pursell ZF, Linn S (Aug 2000). "Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon". J Biol Chem 275 (30): 23247–52. doi:10.1074/jbc.M002548200. PMID 10801849. 
  2. ^ a b Poot RA, Dellaire G, Hulsmann BB, Grimaldi MA, Corona DF, Becker PB, Bickmore WA, Varga-Weisz PD (Oct 2000). "HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins". EMBO J 19 (13): 3377–87. doi:10.1093/emboj/19.13.3377. PMC 313940. PMID 10880450. 
  3. ^ a b "Entrez Gene: POLE3 polymerase (DNA directed), epsilon 3 (p17 subunit)". 

Further reading[edit]