POLK

POLK
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1T94, 2LSI, 2OH2, 2W7O, 2W7P, 3IN5, 3PZP, 4BA9, 4GK5, 4U6P, 4U7C
Identifiers
Aliases	POLK, DINB1, DINP, POLQ, polymerase (DNA) kappa, DNA polymerase kappa
External IDs	OMIM: 605650; MGI: 1349767; HomoloGene: 32140; GeneCards: POLK; OMA:POLK - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	75,601,144 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; corpus callosum; ; superficial temporal artery; ; epithelium of colon; ; mucosa of paranasal sinus; ; skin of hip; ; trabecular bone; ; monocyte; ; islet of Langerhans; ; synovial membrane;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; damaged DNA binding; DNA-directed DNA polymerase activity; DNA binding; nucleotidyltransferase activity; metal ion binding; protein binding;
Cellular component	nucleoplasm; nucleus; nuclear body; site of DNA damage;
Biological process	nucleotide-excision repair, DNA gap filling; DNA replication; translesion synthesis; transcription-coupled nucleotide-excision repair; nucleotide-excision repair, DNA incision; DNA biosynthetic process; nucleotide-excision repair, DNA incision, 5'-to lesion; DNA repair; cellular response to DNA damage stimulus; cellular response to UV; error-prone translesion synthesis; error-free translesion synthesis;
	Sources:Amigo / QuickGO
Orthologs
	51426
	27015
	ENSG00000122008
	ENSMUSG00000021668
	Q9UBT6
	Q9QUG2
	NM_016218; NM_001345921; NM_001345922
	NM_012048
	NP_001332850; NP_001332851; NP_057302; NP_057302.1
	NP_001334531; NP_001334532; NP_001334533; NP_001334535; NP_036178
	Wikidata
View/Edit Human	View/Edit Mouse

DNA polymerase kappa is an DNA polymerase that in humans is encoded by the POLK gene. It is involved in translesion synthesis.^[4]^[5]^[6]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000122008 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ohashi E, Ogi T, Kusumoto R, Iwai S, Masutani C, Hanaoka F, Ohmori H (Aug 2000). "Error-prone bypass of certain DNA lesions by the human DNA polymerase κ". Genes Dev. 14 (13): 1589–94. doi:10.1101/gad.14.13.1589. PMC 316741. PMID 10887153.
^ Gerlach VL, Aravind L, Gotway G, Schultz RA, Koonin EV, Friedberg EC (Nov 1999). "Human and mouse homologs of Escherichia coli DinB (DNA polymerase IV), members of the UmuC/DinB superfamily". Proc Natl Acad Sci U S A. 96 (21): 11922–7. doi:10.1073/pnas.96.21.11922. PMC 18388. PMID 10518552.
^ "Entrez Gene: POLK Polymerase (DNA directed) kappa".

References

Further reading