From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
Available structures
PDB Ortholog search: PDBe RCSB
Aliases POLR3C, RPC3, RPC62, polymerase (RNA) III subunit C, RNA polymerase III subunit C
External IDs MGI: 1921664 HomoloGene: 38185 GeneCards: POLR3C
Gene location (Human)
Chromosome 1 (human)
Chr. Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for POLR3C
Genomic location for POLR3C
Band 1q21.1 Start 145,824,088 bp[1]
End 145,842,505 bp[1]
RNA expression pattern
PBB GE POLR3C 210573 s at fs.png

PBB GE POLR3C 209382 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 1: 145.82 – 145.84 Mb Chr 3: 96.71 – 96.73 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

DNA-directed RNA polymerase III subunit RPC3 is an enzyme that in humans is encoded by the POLR3C gene.[5][6][7]


POLR3C has been shown to interact with GTF3C4.[8][9]

Related gene problems[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000186141 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028099 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Wang Z, Roeder RG (Jun 1997). "Three human RNA polymerase III-specific subunits form a subcomplex with a selective function in specific transcription initiation". Genes Dev. 11 (10): 1315–26. doi:10.1101/gad.11.10.1315. PMID 9171375. 
  6. ^ Hu P, Wu S, Sun Y, Yuan CC, Kobayashi R, Myers MP, Hernandez N (Oct 2002). "Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits". Mol Cell Biol. 22 (22): 8044–55. doi:10.1128/MCB.22.22.8044-8055.2002. PMC 134740Freely accessible. PMID 12391170. 
  7. ^ "Entrez Gene: POLR3C polymerase (RNA) III (DNA directed) polypeptide C (62kD)". 
  8. ^ Hsieh, Y J; Wang Z; Kovelman R; Roeder R G (Jul 1999). "Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III". Mol. Cell. Biol. UNITED STATES. 19 (7): 4944–52. ISSN 0270-7306. PMC 84305Freely accessible. PMID 10373544. 
  9. ^ Hsieh, Y J; Kundu T K; Wang Z; Kovelman R; Roeder R G (Nov 1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Mol. Cell. Biol. UNITED STATES. 19 (11): 7697–704. doi:10.1128/mcb.19.11.7697. ISSN 0270-7306. PMC 84812Freely accessible. PMID 10523658. 
  10. ^ Klopocki E, Schulze H, Strauss G, et al. (February 2007). "Complex inheritance pattern resembling autosomal recessive inheritance involving a microdeletion in thrombocytopenia-absent radius syndrome". Am. J. Hum. Genet. 80 (2): 232–40. doi:10.1086/510919. PMC 1785342Freely accessible. PMID 17236129. 

Further reading[edit]