PON2

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PON2
Identifiers
AliasesPON2, paraoxonase 2
External IDsMGI: 106687 HomoloGene: 385 GeneCards: PON2
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for PON2
Genomic location for PON2
Band7q21.3Start95,404,863 bp[1]
End95,435,329 bp[1]
RNA expression pattern
PBB GE PON2 210830 s at fs.png

PBB GE PON2 201876 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000305
NM_001018161

NM_183308

RefSeq (protein)

NP_000296
NP_001018171

NP_899131

Location (UCSC)Chr 7: 95.4 – 95.44 MbChr 6: 5.26 – 5.3 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serum paraoxonase/arylesterase 2 is an enzyme that in humans is encoded by the PON2 gene.[5][6][7]

This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105854 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032667 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Primo-Parmo SL, Sorenson RC, Teiber J, La Du BN (Sep 1996). "The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family". Genomics. 33 (3): 498–507. doi:10.1006/geno.1996.0225. PMID 8661009.
  6. ^ Mochizuki H, Scherer SW, Xi T, Nickle DC, Majer M, Huizenga JJ, Tsui LC, Prochazka M (Aug 1998). "Human PON2 gene at 7q21.3: cloning, multiple mRNA forms, and missense polymorphisms in the coding sequence". Gene. 213 (1–2): 149–57. doi:10.1016/S0378-1119(98)00193-0. PMID 9714608.
  7. ^ a b "Entrez Gene: PON2 paraoxonase 2".

Further reading[edit]