PON3

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PON3
Identifiers
Aliases PON3
External IDs MGI: 106686 HomoloGene: 37371 GeneCards: PON3
RNA expression pattern
PBB GE PON3 213695 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000940

NM_173006

RefSeq (protein)

NP_000931

NP_766594.1
NP_766594

Location (UCSC) Chr 7: 95.36 – 95.4 Mb Chr 6: 5.22 – 5.26 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Paraoxonase 3, also known as PON3, is a protein which in humans is encoded by the PON3 gene.[3][4]

Function[edit]

This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Primo-Parmo SL, Sorenson RC, Teiber J, La Du BN (May 1996). "The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family". Genomics. 33 (3): 498–507. doi:10.1006/geno.1996.0225. PMID 8661009. 
  4. ^ a b "Entrez Gene: PON3 paraoxonase 3". 

Further reading[edit]