POPDC3

POPDC3
Identifiers
Aliases	POPDC3, POP3, bA355M14.1, popeye domain containing 3, LGMDR26
External IDs	OMIM: 605824; MGI: 1930153; HomoloGene: 32540; GeneCards: POPDC3; OMA:POPDC3 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6q21 Start 105,157,900 bp End 105,180,014 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10 B2|10 23.35 cM Start 45,054,194 bp End 45,194,548 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Skeletal muscle tissue of rectus abdominis biceps brachii muscle of thigh vastus lateralis muscle thoracic diaphragm gastrocnemius muscle Skeletal muscle tissue of biceps brachii glutes deltoid muscle triceps brachii muscle Top expressed in triceps brachii muscle temporal muscle vastus lateralis muscle sternocleidomastoid muscle gastrocnemius muscle digastric muscle ankle medial head of gastrocnemius muscle soleus muscle lumbar spinal ganglion More reference expression data BioGPS n/a
Gene ontology Molecular function cAMP binding nucleotide binding molecular function Cellular component membrane integral component of membrane sarcolemma Biological process biological process regulation of membrane potential heart development skeletal muscle tissue development striated muscle cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64208 78977 Ensembl ENSG00000132429 ENSMUSG00000019848 UniProt Q9HBV1 Q9ES81 RefSeq (mRNA) NM_022361 NM_024286 RefSeq (protein) NP_071756 NP_077248 Location (UCSC) Chr 6: 105.16 – 105.18 Mb Chr 10: 45.05 – 45.19 Mb PubMed search
Wikidata
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Popeye domain-containing protein 3 is a protein that in humans is encoded by the POPDC3 gene.

Function

This gene encodes a member of the POP family of proteins which contain three putative transmembrane domains. This membrane associated protein is predominantly expressed in skeletal and cardiac muscle, and may have an important function in these tissues.

Further reading

• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
• Gudbjartsson DF, Walters GB, Thorleifsson G, et al. (2008). "Many sequence variants affecting diversity of adult human height". Nat. Genet. 40 (5): 609–15. doi:10.1038/ng.122. PMID 18391951.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Sulem P, Gudbjartsson DF, Rafnar T, et al. (2009). "Genome-wide association study identifies sequence variants on 6q21 associated with age at menarche". Nat. Genet. 41 (6): 734–8. doi:10.1038/ng.383. PMID 19448622.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.