PPEF1

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PPEF1
Identifiers
Aliases PPEF1, PP7, PPEF, PPP7C, PPP7CA, protein phosphatase with EF-hand domain 1
External IDs MGI: 1097157 HomoloGene: 55960 GeneCards: PPEF1
RNA expression pattern
PBB GE PPEF1 206547 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006240
NM_152223
NM_152224
NM_152225
NM_152226

NM_011147

RefSeq (protein)

NP_006231
NP_689410
NP_689412

NP_035277.1
NP_035277

Location (UCSC) Chr X: 18.68 – 18.83 Mb Chr X: 160.62 – 160.74 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Serine/threonine-protein phosphatase with EF-hands 1 is an enzyme that in humans is encoded by the PPEF1 gene.[3][4][5]

Function[edit]

This gene encodes a member of the serine/threonine protein phosphatase with EF-hand motif family. The protein contains a protein phosphatase catalytic domain, and at least two EF-hand calcium-binding motifs in its C terminus. Although its substrate(s) is unknown, the encoded protein has been suggested to play a role in specific sensory neuron function and/or development. This gene shares high sequence similarity with the Drosophila retinal degeneration C (rdgC) gene. Several alternatively spliced transcript variants, each encoding a distinct isoform, have been described.[5]

Interactions[edit]

PPEF1 has been shown to interact with Calmodulin 1.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Montini E, Rugarli EI, Van de Vosse E, Andolfi G, Mariani M, Puca AA, Consalez GG, den Dunnen JT, Ballabio A, Franco B (Jul 1997). "A novel human serine-threonine phosphatase related to the Drosophila retinal degeneration C (rdgC) gene is selectively expressed in sensory neurons of neural crest origin". Human Molecular Genetics. 6 (7): 1137–45. doi:10.1093/hmg/6.7.1137. PMID 9215685. 
  4. ^ Sherman PM, Sun H, Macke JP, Williams J, Smallwood PM, Nathans J (Oct 1997). "Identification and characterization of a conserved family of protein serine/threonine phosphatases homologous to Drosophila retinal degeneration C". Proceedings of the National Academy of Sciences of the United States of America. 94 (21): 11639–44. doi:10.1073/pnas.94.21.11639. PMC 23563Freely accessible. PMID 9326663. 
  5. ^ a b "Entrez Gene: PPEF1 protein phosphatase, EF-hand calcium binding domain 1". 
  6. ^ Kutuzov MA, Solov'eva OV, Andreeva AV, Bennett N (May 2002). "Protein Ser/Thr phosphatases PPEF interact with calmodulin". Biochemical and Biophysical Research Communications. 293 (3): 1047–52. doi:10.1016/S0006-291X(02)00338-8. PMID 12051765. 

Further reading[edit]