PPFIBP1

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PPFIBP1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPPFIBP1, L2, SGT2, hSGT2, hSgt2p, PPFIA binding protein 1
External IDsOMIM: 603141 MGI: 1914783 HomoloGene: 2685 GeneCards: PPFIBP1
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for PPFIBP1
Genomic location for PPFIBP1
Band12p11.23-p11.22Start27,523,431 bp[1]
End27,695,564 bp[1]
RNA expression pattern
PBB GE PPFIBP1 203735 x at fs.png

PBB GE PPFIBP1 214374 s at fs.png

PBB GE PPFIBP1 203736 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001198915
NM_001198916
NM_003622
NM_177444

NM_001170433
NM_026221
NM_001355728
NM_001355729

RefSeq (protein)

NP_001185844
NP_001185845
NP_003613
NP_803193

NP_001163904
NP_080497
NP_001342657
NP_001342658

Location (UCSC)Chr 12: 27.52 – 27.7 MbChr 6: 146.89 – 147.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Liprin-beta-1 is a protein that in humans is encoded by the PPFIBP1 gene.[5][6][7]

The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein was found to interact with S100A4, a calcium-binding protein related to tumor invasiveness and metastasis. In vitro experiment demonstrated that the interaction inhibited the phosphorylation of this protein by protein kinase C and protein kinase CK2. Alternatively spliced transcript variants encoding distinct isoforms have been reported.[7]

Interactions[edit]

PPFIBP1 has been shown to interact with liprin-alpha-1.[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000110841 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000016487 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Serra-Pages C, Medley QG, Tang M, Hart A, Streuli M (Jul 1998). "Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins". J Biol Chem. 273 (25): 15611–20. doi:10.1074/jbc.273.25.15611. PMID 9624153.
  6. ^ Kriajevska M, Fischer-Larsen M, Moertz E, Vorm O, Tulchinsky E, Grigorian M, Ambartsumian N, Lukanidin E (Feb 2002). "Liprin beta 1, a member of the family of LAR transmembrane tyrosine phosphatase-interacting proteins, is a new target for the metastasis-associated protein S100A4 (Mts1)". J Biol Chem. 277 (7): 5229–35. doi:10.1074/jbc.M110976200. PMID 11836260.
  7. ^ a b "Entrez Gene: PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)".

Further reading[edit]