PPP3CB

PPP3CB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4OR9, 4ORA, 4ORC
Identifiers
Aliases	PPP3CB, CALNA2, CALNB, CNA2, PP2Bbeta, protein phosphatase 3 catalytic subunit beta
External IDs	OMIM: 114106; MGI: 107163; HomoloGene: 56429; GeneCards: PPP3CB; OMA:PPP3CB - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	73,496,024 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	20,596,641 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; Skeletal muscle tissue of rectus abdominis; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; middle temporal gyrus; ; vastus lateralis muscle; ; lateral nuclear group of thalamus; ; superior frontal gyrus; ; orbitofrontal cortex; ; glutes;
	Top expressed in
	subiculum; ; dorsal striatum; ; triceps brachii muscle; ; olfactory tubercle; ; lateral septal nucleus; ; anterior amygdaloid area; ; medial dorsal nucleus; ; temporal muscle; ; nucleus accumbens; ; sternocleidomastoid muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; phosphoprotein phosphatase activity; protein dimerization activity; protein serine/threonine phosphatase activity; metal ion binding; calmodulin binding; protein binding; enzyme binding; protein phosphatase 2B binding; hydrolase activity; calmodulin-dependent protein phosphatase activity;
Cellular component	cytosol; T-tubule; plasma membrane; calcineurin complex; nucleoplasm; Z discdkac; cytoplasm; glutamatergic synapse;
Biological process	response to cytokine; lymphangiogenesis; regulation of insulin secretion; calcineurin-NFAT signaling cascade; memory; learning; regulation of synaptic plasticity; T cell homeostasis; positive regulation of transcription, DNA-templated; negative regulation of T cell mediated cytotoxicity; T cell proliferation; Fc-epsilon receptor signaling pathway; protein phosphorylation; heart development; T cell differentiation; axon extension; regulation of gene expression; social behavior; positive regulation of insulin secretion involved in cellular response to glucose stimulus; locomotion involved in locomotory behavior; T cell activation; positive regulation of transcription by RNA polymerase II; calcium-ion regulated exocytosis; signal transduction; dephosphorylation; Wnt signaling pathway, calcium modulating pathway; protein dephosphorylation; regulation of synaptic vesicle endocytosis; calcineurin-mediated signaling;
	Sources:Amigo / QuickGO
Orthologs
	5532
	19056
	ENSG00000107758
	ENSMUSG00000021816
	P16298
	P48453
	NM_001142353; NM_001142354; NM_001289968; NM_001289969; NM_021132
	NM_008914; NM_001310426; NM_001310427
	NP_001135825; NP_001135826; NP_001276897; NP_001276898; NP_066955
	NP_001297355; NP_001297356; NP_032940
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein phosphatase 2C catalytic subunit beta isoform is an enzyme that in humans is encoded by the PPP3CB gene.^[5]^[6]^[7] Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000107758 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021816 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Giri PR, Higuchi S, Kincaid RL (Jan 1992). "Chromosomal mapping of the human genes for the calmodulin-dependent protein phosphatase (calcineurin) catalytic subunit". Biochem Biophys Res Commun. 181 (1): 252–8. doi:10.1016/S0006-291X(05)81410-X. PMID 1659808.
^ Guerini D, Krinks MH, Sikela JM, Hahn WE, Klee CB (Mar 1990). "Isolation and sequence of a cDNA clone for human calcineurin B, the Ca2+-binding subunit of the Ca2+/calmodulin-stimulated protein phosphatase". DNA. 8 (9): 675–82. doi:10.1089/dna.1.1989.8.675. PMID 2558868.
^ "Entrez Gene: PPP3CB protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform".

References

Further reading