PREB

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PREB
Identifiers
Aliases PREB, SEC12, prolactin regulatory element binding
External IDs MGI: 1355326 HomoloGene: 40877 GeneCards: PREB
Gene location (Human)
Chromosome 2 (human)
Chr. Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for PREB
Genomic location for PREB
Band 2p23.3 Start 27,130,756 bp[1]
End 27,134,675 bp[1]
RNA expression pattern
PBB GE PREB 217861 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001330484
NM_001330485
NM_001330486
NM_001330487
NM_013388

NM_001294302
NM_016703

RefSeq (protein)

NP_001317413
NP_001317414
NP_001317415
NP_001317416
NP_037520

NP_001281231
NP_057912

Location (UCSC) Chr 2: 27.13 – 27.13 Mb Chr 5: 30.95 – 30.96 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Prolactin regulatory element-binding protein is a protein that in humans is encoded by the PREB gene.[5][6][7]

This gene encodes a protein that specifically binds to a Pit1-binding element of the prolactin (PRL) promoter. This protein may act as a transcriptional regulator and is thought to be involved in some of the developmental abnormalities observed in patients with partial trisomy 2p. This gene overlaps the abhydrolase domain containing 1 (ABHD1) gene on the opposite strand.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138073 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000045302 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Fliss MS, Hinkle PM, Bancroft C (May 1999). "Expression cloning and characterization of PREB (prolactin regulatory element binding), a novel WD motif DNA-binding protein with a capacity to regulate prolactin promoter activity". Mol Endocrinol. 13 (4): 644–657. doi:10.1210/me.13.4.644. PMID 10194769. 
  6. ^ Edgar AJ (Jul 2003). "The gene structure and expression of human ABHD1: overlapping polyadenylation signal sequence with Sec12". BMC Genomics. 4: 18. doi:10.1186/1471-2164-4-18. PMC 156608Freely accessible. PMID 12735795. 
  7. ^ a b "Entrez Gene: PREB prolactin regulatory element binding". 

Further reading[edit]

External links[edit]