PRPF3

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PRPF3
Protein PRPF3 PDB 1x4q.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PRPF3, pre-mRNA processing factor 3, HPRP3, HPRP3P, PRP3, Prp3p, RP18, SNRNP90
External IDs MGI: 1918017 HomoloGene: 3447 GeneCards: PRPF3
RNA expression pattern
PBB GE PRPF3 202251 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004698

NM_027541
NM_001316751

RefSeq (protein)

NP_004689

NP_001303680.1
NP_081817.2
NP_001303680
NP_081817

Location (UCSC) Chr 1: 150.32 – 150.35 Mb Chr 3: 95.83 – 95.86 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

U4/U6 small nuclear ribonucleoprotein Prp3 is a protein that in humans is encoded by the PRPF3 gene.[3]

Function[edit]

The removal of introns from nuclear pre-mRNAs occurs on complexes called spliceosomes, which are made up of 4 small nuclear ribonucleoprotein (snRNP) particles and an undefined number of transiently associated splicing factors. PRPF3 is one of several proteins that associate with U4 and U6 snRNPs.[supplied by OMIM][3]

Interactions[edit]

PRPF3 has been shown to interact with DVL3.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b "Entrez Gene: PRPF3 PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae)". 
  4. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 

Further reading[edit]

External links[edit]