PSCA (gene)

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PSCA
Identifiers
AliasesPSCA, PRO232, prostate stem cell antigen
External IDsMGI: 1919623 HomoloGene: 4150 GeneCards: PSCA
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for PSCA
Genomic location for PSCA
Band8q24.3Start142,670,308 bp[1]
End142,682,724 bp[1]
RNA expression pattern
PBB GE PSCA 205319 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005672

NM_028216

RefSeq (protein)

NP_005663

NP_082492

Location (UCSC)Chr 8: 142.67 – 142.68 MbChr 15: 74.71 – 74.72 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Prostate stem cell antigen is a protein that in humans is encoded by the PSCA gene.[5][6]

This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene has a nonsynonymous nucleotide polymorphism at its start codon.[6]

Clinical significance[edit]

This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000167653 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022598 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Reiter RE, Gu Z, Watabe T, Thomas G, Szigeti K, Davis E, Wahl M, Nisitani S, Yamashiro J, Le Beau MM, Loda M, Witte ON (Mar 1998). "Prostate stem cell antigen: a cell surface marker overexpressed in prostate cancer". Proc Natl Acad Sci U S A. 95 (4): 1735–40. doi:10.1073/pnas.95.4.1735. PMC 19171. PMID 9465086.
  6. ^ a b c "Entrez Gene: PSCA prostate stem cell antigen".

Further reading[edit]